摘要
本文报告并分析了5例脑膜瘤对性激素反应的体外试验结果。试验表明,雌二醇及孕酮均可刺激肿瘤生长,但生理浓度下孕酮的刺激作用较雌二醇强,这与脑膜瘤孕激素受体(PR)占优势的特点一致。孕激素拮抗剂RU486有明显的抑制肿瘤生长作用。本文为脑膜瘤的激素治疗提供了一定的实验依据,其中应以抗孕激素治疗为主,RU486可能有潜在的临床治疗意义。
The responses of meningiomas to sex hormonesin vitro in five cases were observed. The resultsshowed that both estradiol and progesterone promo-ting the growth of tumors. In physiologicalconcentrations, progesterone were stronger than thatof estradiol. This was in accord with the characte-ristic finding that progesterone receptor waspredominant in meningiomas. The action ofantiestrogen tamoxifen to tumors were not consistent.On the contrary, RU486. a progesterone antagonist.caused significant inhibition of cell growth. Basedon the preliminary results, antiprogesterone thearpymay be the primary and hopeful choice and RU486is probably a potential therapeutic agent forunresectable meningiomas.
出处
《中华神经外科杂志》
CSCD
北大核心
1992年第1期21-24,共4页
Chinese Journal of Neurosurgery
