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血糖水平对大鼠急性脑缺血电镜酶细胞化学及超微结构的影响 被引量:50

Effect of blood sugar level on the enzymology and ultrestructure of mitochondria of forebrain in rats with acute brain ischemia.
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摘要 本文采用电镜酶细胞化学方法及图像分析技术(TAS),对不同血糖水平条件下,大鼠双侧颈总动脉闭塞30分钟后,前脑皮质神经元内有琥珀酸脱氢酶(SDH)反应产物的线粒体进行了精确的形态学计量,并对相应的超微结构进行了观察。结果表明高血糖能加剧缺血时线粒体的肿胀和破坏;高血糖组胶质细胞水肿,血脑屏障的胶质膜高度水肿,而正常血糖组及低血糖脑缺血组改变不明显。 Effects of different blood sucar levels on the mitochondria responding to succnic dehydrogenase (SDH),of forebrain in rats undergoing bilateral occlusion of common carotid arteries for 30 minutes were studied bv using electron microscope en-zymlogy combined with texture analysis technique (TAS).The ultrastructure of the mitochondria was also observed in each group.The results showed that the mean number of the mitochondria in hyperglycemic group was significantly lower than in normo-and hypoplycemic groups.The mean mitochondrial area in hypoglycemie group was significantly lower than in hyper and normo-glycemic groups.The asfrocvte and glial membrane of BBB were obviously swelling in hyper-glycemic group.It was revealed that brain ischemia can be aggravated by hyperglycemia and rnild hypo-glycemia may have a protective effect on it.
机构地区 济南部队总医院
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 1992年第4期193-195,T000,共4页 Chinese Journal of Nervous and Mental Diseases
关键词 脑缺血 血糖 线粒体 Brain ischemia Bloodglucose Mitochondrion
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