摘要
本文报告用斑点杂交法测定70例香港华人妇女宫颈癌组织中HPV感染的伴同性,结果显示HPV6、11、16和18型DNA的阳性率分别为8.6%、8.6%、34.2%和15.7%。对48例有完整临床和病理资料的结果作进一步分析显示,临床分期和肿瘤分化程度与HPV感染的型别有一定的关系。病理分化差的宫颈癌中,HPV18DNA阳性率显著高于分化好的宫颈癌,结果提示HPV18感染可能伴同一组侵润性强的宫颈癌。
In this series of 70 Hong kong Chinese women with cervical can-cers ah investigation was carried out for the presence of human papillomarirus (HPV)-type 6,11, 16 and 18 by dot blot hybridization. HPV-type 6, 11, 16 and 18 infections were found to be present in 8.6%,8.6%, 34.2%and 15.7%in specimens, respectively. Complete clinical information was obtained in 48 cases by chart review, of the factors evaluated, clinical stage and tumor differentiation were found to have statistically significant relationship to HPV-type. The result suggests that the HPV 18 may be associated with a more aggressive form of cervical cancer than other HPV types.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1993年第1期42-44,共3页
Chinese Journal of Cancer
关键词
乳头状瘤病毒
宫颈癌
斑点杂交法
Papillomavirus cervical carcinoma do.t blot hybridization