血清HE4、血小板检测联合MRI对子宫内膜癌肌层浸润的研究进展

Advances in Serum HE4 and Platelet Detection Combined with MRI in the Treatment of Endometrial Carcinoma

子宫内膜癌(EC)是女性生殖系统三大恶性肿瘤之一,近年来,其发病率及病死率有逐渐升高且呈年轻化趋势。准确评估浸润深度和术前分期对于子宫内膜癌患者是很重要的。作为新型的肿瘤标志物HE4,在早期EC诊断及预后中可以作为一个有用的血清学标记。血小板参数的改变可协助子宫内膜癌病情评估及预后判断。磁共振(MRI)检查在EC宫颈受累及肌层浸润深度有良好的敏感度与特异度。因此本文将对肿瘤标志物HE4、血小板参数及MRI在子宫内膜癌肌层浸润中的意义进行叙述。

Endometrial cancer (EC) is one of the three malignant tumors of the female reproductive system. In recent years, its incidence and mortality have been increasing gradually and at a younger age. Accurate assessment of infiltration depth and preoperative staging is important for patients with endometrial cancer. As a novel tumor marker HE4, it can be used as a useful serological marker in early EC diagnosis and prognosis. The changes of platelet parameters can assist the assessment and prognosis of endometrial cancer. Magnetic resonance imaging (MRI) showed good sensitivity and specificity in EC cervical involvement and muscle infiltration depth. Therefore, the significance of tumor marker HE4, platelet parameters and MRI in muscular invasion of endometrial carcinoma will be described in this paper.