摘要
目的:观察异位消癥汤辅助甲氨蝶呤(MTX)宫颈注射联合米非司酮(RU486)口服治疗异位妊娠的临床疗效。方法:选择我院2019年7月~2021年6月符合保守治疗原则的异位妊娠患者124例,采用完全随机法将患者分为观察组和对照组,每组患者62例,对照组予MTX宫颈注射及RU486口服;观察组在对照组基础上加用异位消癥汤口服;治疗的第4、7、14天复查血清人绒毛膜促性腺激素(β-HCG)水平,若血清β-HCG水平下降幅度【15%,则继续进行第二疗程的治疗。之后每周复查血β-HCG水平、肝肾功能、血常规及经阴道超声检查,对比两组的治疗效果。结果:观察组的有效率为93.55%,对照组有效率为80.64%;两组组间比较表明观察组有效率高于对照组,差异有统计学意义(P 【0.05)。结论:异位消癥汤辅助甲氨蝶呤宫颈注射联合米非司酮片口服治疗异位妊娠疗效满意,值得临床推广应用。
Objective: The clinical efficacy of Yiwei Xiaozheng decoction with methotrexate (MTX) cervical injec-tion combined with mifepristone (RU486) oral treatment of ectopic pregnancy was observed. Method: 124 ectopic pregnant patients in line with conservative treatment principles from July 2019 to June 2021 were selected, and the patients were divided into control group and observation group by random number table method, 62 patients in each group, and the control group was given MTX cervical injection and RU486 oral administration. The observation group added Yiwei Xiaozheng decoction to the control group;Serum human chorionic gonadotropin (β-HCG) levels are reviewed on days 4, 7, and 14 of treatment, and if serum β-HCG decreases by <15%, a second course of treatment is continued. Blood β-HCG levels, liver and kidney function, complete blood count, and transvaginal ultrasound were followed weekly to compare the treatment effects of the two groups. Results: The effectiveness rate of the observation group was 93.55%, and the effectiveness rate of the control group was 80.64%. A comparison between the two groups showed that the efficiency of the observation group was higher than that of the control group, and the difference was statistically significant (P <0.05). Conclusion: Yiwei Xiaozheng decoction assisted methotrexate cervical injec-tion combined with mifepristone tablets oral treatment of ectopic pregnancy is satisfactory and worthy of clinical promotion and application.
出处
《临床医学进展》
2022年第5期4503-4510,共8页
Advances in Clinical Medicine
