川崎病休克综合征诊治进展

Progress in the Diagnosis and Treatment of Kawasaki Disease Shock Syndrome

川崎病(Kawasaki disease, KD)是一种常见于儿童的免疫性血管炎症,是儿童后天获得性心脏病的主要原因。川崎病休克综合征(Kawasaki disease shock syndrome, KDSS)是川崎病的一种少见且严重亚型,休克发生可能与高炎症反应、毛细血管持续渗漏、心肌功能障碍、对超抗原过度反应相关。KDSS常发生在疾病早期阶段,临床症状不典型,常合并有多系统损害,容易误诊。因此,需提高临床医生对KDSS的认识,早期诊断并及时治疗以控制其发生发展。本文就KDSS诊治进展进行综述。

Kawasaki disease (KD) is an immune vascular inflammation that is common in children and is the main cause of acquired heart disease in children. Kawasaki disease shock syndrome (KDSS) is a rare and severe subtype of Kawasaki disease. The occurrence of shock may be related to high inflamma-tory response, continuous capillary leakage, myocardial dysfunction, and overreaction to superan-tigens. KDSS often occurs in the early stage of the disease, with atypical clinical symptoms, often combined with multi-system damage, and easy to be misdiagnosed. Therefore, it is necessary to improve clinicians’ understanding of KDSS, in order to make early diagnosis and timely treatment to control its occurrence and development. This article reviews the progress in the diagnosis and treatment of KDSS.