摘要
种族性或民族性是众所周知的影响糖尿病发生发展的重要因素。验证2型糖尿病(T2DM)易感基因CDKAL1 (CDK5调节亚基相关蛋白1类似物1)位点与民族、种族的关联性,为本地区少数民族易感人群的筛选和疾病分子分型提供基础。选取近5年相关文献分析CDKAL1基因及不同基因位点在T2DM不同人群中的相关性,进一步了解CDKAL1基因单核苷酸多态性(SNPs)与2型糖尿病风险之间存在的关联。
Ethnicity or nationality is known to be an important factor influencing the development of diabetes mellitus. To validate the association of CDKAL1 (CDK5 regulatory subunit-associated protein 1 ana-logue 1) locus with ethnicity and race in type 2 diabetes mellitus (T2DM) susceptibility gene, to provide a basis for screening and molecular typing of disease in susceptible populations of ethnic minorities in our region, we selected relevant literature in the past 5 years to analyze the correla-tion between CDKAL1 gene and different loci in different populations of T2DM, and to further un-derstand the association between single nucleotide polymorphisms (SNPs) of CDKAL1 gene and the risk of type 2 diabetes.
出处
《临床医学进展》
2023年第6期9363-9367,共5页
Advances in Clinical Medicine
