烯烃的不对称官能化反应研究进展

Research Progress in Asymmetric Functionalization of Olefins

由于C=C键的存在,烯烃被认为是现代有机化学中最有吸引力的底物之一。利用金属催化剂和有机催化剂在烯烃上催化加成H-Y (Y = H, B, C, N, Si等)是生成新的C-H键和C-Y键最常用和最有效的方法之一。不对称烯烃的氢官能化提供了一个直接的策略,以获得对映异构富集的分子。本文综述了利用金属和有机催化剂催化烯烃的不对称加氢官能化反应研究的进展。

Olefins are considered to be one of the most attractive substrates in modern organic chemistry due to the existence of the C=C bond. The catalytic addition of H-Y (Y = H, B, C, N, Si, etc.) on olefins using metal catalysts and organic catalysts is one of the most commonly used and effective methods to generate new C-H bonds and C-Y bonds. Hydrogen functionalization of asymmetric olefins provides a direct strategy to obtain enantioenriched molecules. In this paper, the research progress of asymmetric hydrogenation functionalization of olefins catalyzed by metal and organic catalysts is reviewed.