基于CRISPR/Cas系统的即时诊断研究进展

Progress in Point-of-Care Diagnosis Based on CRISPR/Cas System

面对突发公共卫生事件,快速、准确和便携的现场检测至关重要。基于CRISPR/Cas技术的分子诊断是目前现场检测主要方法,可以与多种信号传感方法相结合,集成到智能设备中,开发多个检测新平台。本文介绍基于CRISPR/Cas系统的传感器发展和现场应用,对CRISPR和现场检测的发展前景进行总结和展望。

Fast, accurate and portable onsite testing is critical in the face of public health emergencies. Molecular diagnosis based on CRISPR/Cas technology is currently the main method of detection, which can be combined with a variety of signal sensing methods, integrated into smart devices, and develop multiple new detection platforms. This paper introduces the sensor development and field application based on CRISPR/Cas system, and summarizes and prospects the development prospect of CRISPR and field detection.