宫颈巴氏涂片与液基薄层技术对宫颈病变诊断效果比较

Comparative analysis of Pap smear and liquid-based thin-layer technique in cervical pathology

目的宫颈病变具有癌变倾向,有发展为恶性肿瘤的潜能,长期存在可转变为宫颈癌。本研究通过对比分析病理技术中液基薄层细胞学技术和宫颈巴氏涂片两种检查方法对宫颈病变的诊断结果,探讨对宫颈癌筛查的意义。方法选择2018-03-30-2019-03-30郑州人民医院病理科收诊的75例宫颈病变筛查患者为研究对象,均行宫颈巴氏涂片、液基薄层细胞学技术检查,统计分析两种检查方式的结果,并以病理活检结果为金标准,比较这两种检查方法的诊断准确率。结果液基薄层细胞学技术阳性检出率为68.00%,宫颈巴氏涂片为74.67%,两种检查方法比较差异有统计学意义,χ~2=8.335,P=0.003。液基薄层细胞学技术和宫颈巴氏涂片的诊断准确率分别为92%和73.33%,差异有统计学意义,χ~2=15.629,P=0.019;特异性分别为87.5%和58.33%,差异有统计学意义,χ~2=13.704,P=0.023;敏感性分别为94.12%和80.39%,差异有统计学意义,χ~2=10.318,P=0.004。结论液基薄层细胞学技术对宫颈病变诊断的特异性高、敏感性高及准确率高,可为宫颈癌筛查提供有利依据。

OBJECTIVE Cervical lesions have a tendency to become cancerous,have the potential to develop into malignant tumors,and can be transformed into cervical cancer for a long period of time.This paper analyzes two pathological techniques(liquid-based thin-layer cytology technique and cervical Pap smear)in a comparative analysis.The pathological biopsy results were used as the gold standard to compare the diagnostic accuracy of the two methods.METHODS Seventy-five patients with cervical lesions screened in the Department of Pathology of Zhengzhou People’s Hospital from March 30,2018 to March 30,2019 were selected for study.The results of the two examination methods were statistically analyzed,and the pathological biopsy results were used as the gold standard to compare the diagnostic accuracy of the two examination methods.RESULTS Pathological biopsy results were used as the gold standard.The positive detection rate of liquid-based thin-layer cytology was 68.00%,and the Pap smear of the cervix was 74.67%.The difference between the two methods was statistically significant(χ~2=8.335,P=0.003).The diagnostic accuracy of liquidbased thin-layer cytology and cervical Pap smears were 92% and 73.33%,respectively,and the differences were statistically significant(χ~2=15.629,P=0.019).The specificities were 87.5% and 58.33%,respectively.There was statistical significance(χ~2=13.704,P=0.023),The sensitivity was 94.12% and 80.39%,respectively,and the difference was statistically significant(χ~2=10.318,P=0.004).CONCLUSION Liquid-based thin-layer cytology has high specificity,sensitivity and accuracy in the diagnosis of cervical lesions,which can provide a useful basis for cervical cancer screening.