多囊卵巢综合征患者miRNAs差异表达的研究进展

ADVANCES IN DIFFERENTIAL EXPRESSION OF miRNAs IN POLYCYSTIC OVARY SYNDROME

微小核糖核酸(microRNA,miRNAs)是短链非编码RNA,在组织发育和分化过程中对转录后基因表达的调节至关重要。它们参与多种生物调节,并且在女性生殖系统参与卵母细胞成熟和卵泡发育,尤其在多囊卵巢综合征(polycystic ovary syndrome,PCOS)中观察到了miRNAs水平的改变。近年来在多囊卵巢综合征患者的颗粒细胞、卵泡液以及外周血中均发现miRNAs有差异性表达,推测它可能是一种潜在的生物标志物,并可能成为诊断和治疗多囊卵巢综合征的新的靶点。本文就miRNAs与多囊卵巢综合征关系的最新研究进展进行综述,并探讨其在多囊卵巢综合征的发病机制以及临床诊断中的潜在作用。

MicroRNA are short non-coding RNAs that are critical for the regulation of post-transcriptional gene expression during tissue development and differentiation.They are involved in a variety of biological regulation and are involved in oocyte maturation and follicle development in the female reproductive system.In particular,altered miRNAs levels were observed in polycystic ovary syndrome(PCOS).In recent years,miRNA has been found to be differentially expressed in granulosa cells,follicular fluid and peripheral blood of PCOS patients,which is speculated to be a potential biomarker and a new therapeutic target for the diagnosis and treatment of PCOS.In this review,the recent research progress on the relationship between miRNAs and PCOS is reviewed,and the potential role of mirnas in the pathogenesis and clinical diagnosis of PCOS is discussed.