期刊文献+

The role of α- and β-adrenergic receptors in the spasmolytic effects on rat ileum of Petroselinum crispum Latifolum(parsley) 被引量:1

The role of α- and β-adrenergic receptors in the spasmolytic effects on rat ileum of Petroselinum crispum Latifolum(parsley)
下载PDF
导出
摘要 Objective:To investigate Petroselinum crispum Latifolum(parsley) for treating stomach and intestinal disorders in Iran.Methods:An 80%ethanol extract was prepared from parsley seeds, and its antispasmodic activity assessed by measuring contractions of isolated ilea induced by 60 mM potassium chloride(KG).A piece of ileum from an adult male Wistar rat was dissected and mounted in an organ bath containing Tyrode’s solution,and ileum contractions were recorded by an isotonic transducer under one gram resting tension.The effect of parsley extract was measured in the presence of two antagonists’ of a - and(5-adrenoceptors.Results:These experiments showed that parsley extract inhibited the response to 60 mM KC1 in a concentration-dependent manner(P【0.01,n=7).The spasmolytic effect of parsley extract was unaffected by 1μM phentolamine or 1μM propranolol.Conclusions:This study shows that parsley seed extract is a relaxant of isolated rat ileum and the relaxation effect of extract does not involved adrenergic receptors. Objective:To investigate Petroselinum crispum Latifolum(parsley) for treating stomach and intestinal disorders in Iran.Methods:An 80%ethanol extract was prepared from parsley seeds, and its antispasmodic activity assessed by measuring contractions of isolated ilea induced by 60 mM potassium chloride(KG).A piece of ileum from an adult male Wistar rat was dissected and mounted in an organ bath containing Tyrode's solution,and ileum contractions were recorded by an isotonic transducer under one gram resting tension.The effect of parsley extract was measured in the presence of two antagonists' of a - and(5-adrenoceptors.Results:These experiments showed that parsley extract inhibited the response to 60 mM KC1 in a concentration-dependent manner(P<0.01,n=7).The spasmolytic effect of parsley extract was unaffected by 1μM phentolamine or 1μM propranolol.Conclusions:This study shows that parsley seed extract is a relaxant of isolated rat ileum and the relaxation effect of extract does not involved adrenergic receptors.
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2010年第11期866-870,共5页 亚太热带医药杂志(英文版)
基金 supported by the Department of Biology,Shahid Chamran University,Ahwaz,Iran
关键词 Petroselinum crispum Latifolum ADRENERGIC RECEPTORS RELAXATION ILEUM Petroselinum crispum Latifolum Adrenergic receptors Relaxation Ileum
  • 相关文献

参考文献35

  • 1Patumi M,Fontanazza G,Aldonil B,Barmbill I.Determination of some precursors of lipid biosynthesis in olive fruits during ripening. Acta Horticulturae . 1990
  • 2Fejes S,Krey A,Blazovics A,Luqasi A,Lemberkovics E,Petri G, et al.Investigation of the in vitro antioxidant effect of Petroselinum crispum (Mill.) Nym.ex A.W.Hill. Acta Pharmaceutica Hungarica . 1998
  • 3Wikberg J.Localization of adrenergic receptors in guinea pig ileum and rabbit jejunum to cholinergic neurons and to smooth muscle cells. Acta Physiologica Scandinavica . 1977
  • 4D.Dahiru,J.M.Sini,L.John-Africa."Antidiarrhoeal activity of Ziziphus mauritiana root extract in rodents,". African Journal of Biotechnology . 2006
  • 5Ratz PH,Berg KM,Urban NH,Miner AS.Regulation of smooth muscle calcium sensitivity:KCI as a calcium-sensitizing stimulus. American Journal of Physiology Cell Physiology . 2005
  • 6Oprins JCJ,Vander Burg C,Meijer HP,Munnik T,Groot JA.PLD pathway involved in carbachol-induced Cl secretion:Possible role of TNF-α. American Journal of Physiology Cell Physiology . 2001
  • 7Viramontes BE,Malcolm A,Camilleri M,Szarka LA,McKinzie S,Burton DD,Zinsmeister AR.Effects of an alpha(2)-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans. American Journal of Physiology Gastrointestinal and Liver Physiology . 2001
  • 8Kadowaki M,,Yoneda S,Takaki M.Involvement of a purinergic pathway in the sympathetic regulation of motility in rat ileum〔J〕. Autonomic Neuroscience . 2003
  • 9SJ Roberts,M Papaioannou,BA Evans,RJ Summers.Characterization of β-adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for β1-, β2- and β3-adrenoceptors in rat ileum. British Journal of Pharmacology . 1999
  • 10Storr M,Franck H,Saur D,Schusdziarra V and Allescher HD.Mechanisms of α, βmethylene ATP-induced inhibition in rat ileal smooth muscle: Involvement of intracellular Ca2+ stores in purinergic inhibition. Clinical and Experimental Pharmacology and Physiology . 2000

同被引文献15

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部