摘要
Many kinds of channel currents are especially weak and the background noise dominates in the patch clamp recordings. This makes the threshold detection fail during estimating of the transition probabilities. So direct fitting of the patch clamp recording, not of the histogram coming from the recordings, is a desirable way to estimate the transition probabilities. Iterative batch EM algorithm based on hidden markov model has been used in this field but which has the "curse of dimensionality" and besides cant keep tracking the varying of the parameters. A new on line sequential iterative one is proposed here, which needs fewer computational efforts and can adaptively keep tracking the varying of parameters. Simulations suggest its robust, effective and convenient.
Many kinds of channel currents are especially weak and the background noise dominates in the patch clamp recordings. This makes the threshold detection fail during estimating of the transition probabilities. So direct fitting of the patch clamp recording, not of the histogram coming from the recordings, is a desirable way to estimate the transition probabilities. Iterative batch EM algorithm based on hidden markov model has been used in this field but which has the 'curse of dimensionality' and besides cant keep tracking the varying of the parameters. A new on line sequential iterative one is proposed here, which needs fewer computational efforts and can adaptively keep tracking the varying of parameters. Simulations suggest its robust, effective and convenient.
