摘要
A new approach to optically active β-alkyl-α-methylene-γ-butyrolactone derivatives was reported from the Rhodococcus sp. AJ270-catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of the amidase has been observed when a methyl protection was introduced into the hydroxy group of the parent substrate.
A new approach to optically active β-alkyl-α-methylene-γ-butyrolactone derivatives was reported from the Rhodococcus sp. AJ270-catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of the amidase has been observed when a methyl protection was introduced into the hydroxy group of the parent substrate.
基金
theMajorStateBasicResearchDevelopmentProgram (No.2 0 0 0 0 775 0 6 ) ,andtheNationalNaturalScienceFoundationofChina (No .2 0 0 0 32 0 2 0 )andChineseAcademyofSciences
