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THE IMMUNOREGULATORY EFFECT OF TLSF_(JM) ON THE EXPRESSION OF T CELL IL-2R AND PROTEIN TYROSINE PHOSPHORYLATION

THE IMMUNOREGULATORY EFFECT OF TLSF_(JM) ON THE EXPRESSION OF T CELL IL-2R AND PROTEIN TYROSINE PHOSPHORYLATION
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摘要 The immunoregulatory effect of TLSFJM on the expression of T cell IL- 2R and protein tyrosine phosphorylation ( PTP ) was investigated by immunohistochemistry technique. The results showed that TLSFJMcan markedly suppress the expression of IL-2R and PTP on PHA or TPA-stimulated human PBMC and murine IL-2 dependent cell line CTLL-2. However, there was no effect of TLSFJMon the production of IL-1, IL-2 and IL-6 that play an important role in the course of T lymphocyte proliferation and differentiation. The immunoregulatory effect of TLSFJM on the expression of T cell IL- 2R and protein tyrosine phosphorylation ( PTP ) was investigated by immunohistochemistry technique. The results showed that TLSFJMcan markedly suppress the expression of IL-2R and PTP on PHA or TPA-stimulated human PBMC and murine IL-2 dependent cell line CTLL-2. However, there was no effect of TLSFJMon the production of IL-1, IL-2 and IL-6 that play an important role in the course of T lymphocyte proliferation and differentiation.
出处 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1991年第4期10-15,共6页 中国癌症研究(英文版)
关键词 inhibitory factor T lymphocyte activation protein tyrosine phosphorylation. immunoregulation. inhibitory factor, T lymphocyte activation, protein tyrosine phosphorylation. immunoregulation.
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参考文献13

  • 1朱勇,金伯泉,黄传书,刘雪松.条件培养液中杂交瘤生长因子对人—鼠杂交瘤生长、克隆化及抗体分泌的影响[J].中国免疫学杂志,1991,7(2):75-78. 被引量:3
  • 2黄传书,金伯泉,汪美先,周永兴,李恩善.肾综合征出血热患者外周血全淋巴细胞和异型淋巴细胞IFN—γ与其表型的研究[J].中国免疫学杂志,1989,5(4):201-203. 被引量:12
  • 3Gearing AJ. H. et al.A simple sensitive bioassay for interleukin-1 which is unresponsive to 10 μ/ml of interleukin-2. Journal of Immunological Methods . 1987
  • 4Droge W.Protein Kinase C in T-cell regulation. J Immunol . 1986
  • 5Schrezenmeier H,et al.A regulatory role for the CD4 and CD8 molecules in T cell activation. J Immunol . 1988
  • 6Holan V,et al.Establishment and characterization of a permanent T-cell line producing an antigen non-specific suppressor factor. Immunology . 1985
  • 7Sugimura Kazuhisa,et al.A lymphocyte ??blastogenesis inhibitory factor (LBIF) arrests mitogen-stimulated T lymphocytes at early G1 phase with no influence on IL-2 production and IL-2 receptor light chain expression. European Journal of Immunology . 1989
  • 8Robbins PD,Horowitz JM,Mulligan RC.Negative regulation of human c-fos expression by the retinoblastoma gene product. Nature . 1990
  • 9Vivier E,et al.Tyrosine phosphorylation of the FcrR Ⅲ (CD16) : ξ complex in human nature killer cells. J Immunol . 1991
  • 10Santoli D,et al.A suppressor lymphokine produced by human T leukemia cell lines. The Journal of Experimental Medicine . 1986

二级参考文献1

  • 1崔运昌,朱勇,高磊,安献禄,甄荣芬,曾毅.肾综合征出血热病毒的人单克隆抗体的产生和初步鉴定[J]解放军医学杂志,1987(04).

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