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Runx3 might participate in regulating dendriti cell function in patients with irritable bowel syndrome 被引量:1

Runx3 might participate in regulating dendriti cell function in patients with irritable bowel syndrome
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摘要 Objective:To evaluate the expression levels and correlations among the expressions of transforming growth factor-β1(TGF-β1),Kunx3 and CD83 in colonic mucosal specimens from IBS patients.Methods:A total of 40 patients were selected,who were confirmed as IBS by Rome III standard and 40 healthy volunteers served as control.Colonic mucosal specimens of each subject were collected from colon sigmoideum with biopsy forceps.Runx3,TGF-β1?and CD83(the marker for immunecompetent mature dendritic cells(DCs)mRNA in the sigmoid colon tissue were measured by real-time fluorescence quantitative PCR.Results:Compared with the control group,CD83 mRNA expressions were higher in patients with IBS than in healthy controls(P【0.05)and were associated with runt-related transcription factor 3(Runx3)mRNA levels(r=-0.361,P【0.05).Meanwhile,Runx3 mRNA levels were associated with TGF-β1,mRNA expressions in irritable bowel syndrome(IBS)patients(r=0.402,P【0.05).However,there was no correlation between the mRNA expressions of TGF-β1 and CD83(P】0.05).Conclusions:The increase of abnormal dendritic cells might influence the occurrence and development of IBS.TGF-β1 signal pathway might not be involved in Runx 3-regulated maturation of dendritic cells in IBS. Objective:To evaluate the expression levels and correlations among the expressions of transforming growth factor-β_1(TGF-β_1),Kunx3 and CD83 in colonic mucosal specimens from IBS patients.Methods:A total of 40 patients were selected,who were confirmed as IBS by Rome III standard and 40 healthy volunteers served as control.Colonic mucosal specimens of each subject were collected from colon sigmoideum with biopsy forceps.Runx3,TGF-β_1?and CD83(the marker for immunecompetent mature dendritic cells(DCs)mRNA in the sigmoid colon tissue were measured by real-time fluorescence quantitative PCR.Results:Compared with the control group,CD83 mRNA expressions were higher in patients with IBS than in healthy controls(P<0.05)and were associated with runt-related transcription factor 3(Runx3)mRNA levels(r=-0.361,P<0.05).Meanwhile,Runx3 mRNA levels were associated with TGF-β_1,mRNA expressions in irritable bowel syndrome(IBS)patients(r=0.402,P<0.05).However,there was no correlation between the mRNA expressions of TGF-β_1 and CD83(P>0.05).Conclusions:The increase of abnormal dendritic cells might influence the occurrence and development of IBS.TGF-β_1 signal pathway might not be involved in Runx 3-regulated maturation of dendritic cells in IBS.
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第9期754-756,共3页 亚太热带医药杂志(英文版)
基金 supported by Key Science and Technology Project of Hainan Province(Grant No.ZDXM20100042)
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  • 1Hsing-Feng Lee,Jen-Chuen Hsieh,Ching-Liang Lu,Tzu-Chen Yeh,Cheng-Hao Tu,Chou-Ming Cheng,David M. Niddam,Han-Chieh Lin,Fa-Yauh Lee,Full-Young Chang.Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients[J].Pain.2012(6)
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