CCK-8在胆石症患者血浆中的水平变化及其临床意义

Clinical Significance of Changes of Plasma CCK-8 Levels in Patients with Cholelithiasis

目的 :研究CCK - 8在胆石症患者血浆中水平的变化及临床意义。方法 :应用放射免疫分析了 6 0例胆石症患者组术前CCK - 8水平与对照组 (30例无胆囊结石 )患者血浆中CCK - 8水平 ;患者组术前及术后2周CCK - 8水平的比较。结果 :患者组血浆CCK - 8水平为 (4 2 91± 2 88) pmol/L ,显著地高于对照组 (31 5 0± 1 6 2 ) pmol/L ,P <0 0 5 ;患者组术前血浆CCK - 8水平为 (4 2 91± 2 88) pmol/L ,显著地高于术后 (34 2 1±2 5 6 )pmol/L ,P <0 0 5。结论 :胆石症血浆中CCK - 8术前水平为 (4 2 91± 2 88)pmol/L ,显著高于对照组(31 5 0± 1 6 2 ) pmol/L(P <0 0 5 ) ,可作为胆石症诊断指标之一。

Objective To study the clinical significance of changes of plasma cholecystokinin-8 (CCK-8) levels in patients with cholelithiasis. Methods Plasma CCK-8 levels were detected with RIA in 60 patients with cholelithiasis both before and after cholecystectomy and in 30 controls as well. Results Before operation, the plasma CCK-8 levels in patients with cholelithiasis were significantly higher than those in the controls (42.91±2.88 pmol/L vs 31.50±1.62 pmol/L, P<0.05). After cholecystectomy, the levels dropped significantly to 34.21±2.56 pmol/L (vs before operation, P<0.05). Conclusion The high CCK-8 plasma level in patients with chloelithiasis might be a useful marker for clinical diagnosis.