含硫希夫碱过渡金属配合物及其抗癌活性的研究Ⅴ.3-乙酰吡啶缩氨基硫脲与ZnX_2.CuX_2.NiX_2的配合物及其抗癌活性

STUDY ON THE TRANSITION METAL COMPLEXES OF SCHIFF BASES WITH SULPHUR DONOR AND THEIR ANTITUMOR ACTIVITIES Ⅴ. 3-ACETYLPYRIDINE THIOSEMICARBAZONE COMPLEXES WITH ZnX_2, CuX_2, NiX_2 and THEIR ANTITUMOR ACTIVITIES

合成和表征了3-乙酰吡啶缩氨基硫脲与Zn(Ⅱ)Cu(Ⅱ)Ni(Ⅱ)的六个配合物,并用体外试管法测试了配体和配合物的抗癌活性。结果表明:3-乙酰吡啶是通过亚胺基N原子和S原子与金属离子形成配合物,这些配合物的抗癌活性均强于自由配体,Zn(Ⅱ)和Cu(Ⅱ)配合物对腹水癌细胞的杀死率均为100%.

Six complexes of 3-acetylpyridine thiosemicarbazone (HL) with their salts of Zn, Cu, Ni were synthesized and characterized. The antitumor activities of ligands and complexes were investigated on tumor cell(Erlich cell) in vitro. The results reveal that the transition metal ions are coordinated with HL through the imide N atom and thiocarbonyl S atom to form chelates. All the complexes exhibit the higher antitumor activities as compared with the free ligand. For the complexes of copper and zinc,the death ratio of cancer cell is 100%.