左金丸与反左金的方证对应实验研究

Experiment of Zuojin Pills and Retro-ZuoJin by prescription corresponding to syndrome method

目的方证对应地比较研究左金丸与反左金的作用差异。方法选用SD大鼠 ,以辣椒煎液和无水乙醇造成胃热证模型 ,以冰水和氢氧化钠造成胃寒证模型 ,比较左金丸和反左金对两个模型胃黏膜损伤的防治作用。结果左金丸能明显防治胃热证模型大鼠的胃黏膜损伤 (P <0 .0 0 1) ,对胃寒证模型则相对较差 ;与其相反 ,反左金对热模型无效 ,但能明显减轻胃寒证胃黏膜损伤 (P <0 .0 0 1)。结论本研究验证了左金丸、反左金“寒能治热 ,热能治寒”的临床证治规律 。

Objective To compare the different effects of Zuojin pills and Retro-ZuoJin by prescription corresponding to syndrome method. Methods the rats model of hot-stomach syndrome was established by oral administration with anhydrous alcohol and pepper decoction; And the rats model of cold-stomach syndrome was established by oral administration with ice water and sodium hydroxide. Based on these two models, the effects of Zuojin pills and Retro-ZuoJin were compared. Results Zuojin pills could distinctly prevent and cure hot gastric mucosa lesion (P<0.001), but acted relatively poor in cold-stomach syndrome model. On the contrary, Retro-zuojin seemed to have no-effect in hot-stomach syndrome model, but it was suitable for cold gastric mucosa lesion (P<0.001). Conclusion this research verified the clinical regulation of Zuojin pills and Retro-ZuoJin and provided the experimental basis to the principle of treatment according to differentiation of symptoms and signs.