武威市胃癌遗传因素研究

Study on genetic factors of gastric cancer in Wuwei

目的 :探讨武威市胃癌的遗传因素。方法 :应用移民流行病学研究方法对移居新疆奇台县的武威籍居民的胃癌患病情况进行调查 ;根据胃癌死亡登记资料采用Poisson(泊松 )分布模型拟合 ,并用频数分布拟合优度的 χ2 检验进行验证。胃癌家族史调查采用病例 -对照研究方法 ,对有家族史的胃癌分布用二项分布 (p +q) n 模型拟合。胃癌的分离比、遗传度分别采用Li Mantel Cart法与Falconer回归法估算。结果 :移民胃癌一代及后裔均较祖籍武威同期的死亡率 ( 5 7 61/10万 )为低 ,但高于定居地奇台县同期死亡率 ( 2 3 67/10万 )的水平。胃癌在以村为单位和家族中呈现地区和家族聚集性 ,P <0 0 1。胃癌的分离比为 0 0 774,显著<0 2 5。胃癌一级亲属的遗传度为 2 2 91% ,二级亲属遗传度为 2 0 0 7%。结论 :武威市胃癌发病存在遗传易感性 ,遗传所起的作用占 1/4～ 1/5 ,遗传方式为多基因遗传。

OBJECTIVE:To explore the genetic factors of gastric cancer in Wuwei city.METHODS:Using the epidemiology of migrant, we investigated the ocurrence of gastric cancer in the people of Qitai County of Xinjiang Uygur Autonomous Region who immigrated from Wuwei.According to the information of GC-death registered, we fitted it with Possion-distribution model,and then tested the fitted result with case-control study. The GC prevalence of GC family history was fitted with (p+q)n model. The GC's segregation and heritability with Li-Mantel-Cart test and Falconer-regression test were estimated.RESULTS:Death-ratio of the first-generation and their descendants was lower than that of the generation in Wuwei(57.61/100 000), higher than that of the generation in Qitai County (23.67/100 000).The GC prevalence of probands had county and family aggregation, P<0.01.The segregation ratio of GC was 0.077 4, significantly lower than 0.25.The heritabilities of GC were 22.91% and 20.07% in first-degree and second-degree relatives respectively.CONCLUSIONS: Genetic susceptibility (factor) has something to do with the prevalence of GC in Wuwei. It accounts for 1/4-1/5 proportion.The genetic pattern is multi-genes geneticity.