三七总皂甙对脑出血大鼠前脑碱性成纤维细胞生长因子受体影响的实验研究

Study on Expression of Fibroblast Growth Factor Receptor-1 after lntracerebral Hemorrhage and Treatment Effect of Panax Notoginseng Saponins

目的 :研究三七总皂甙对脑出血大鼠脑内碱性成纤维细胞生长因子 (FGFR1 )表达的影响及可能机制。方法 :用免疫组化方法观察胶原酶诱导的脑出血大鼠脑内 FGFR1在给药组和对照组的表达变化。结果 :脑出血后脑内 FGFR1主要在病灶周围、扣带皮质、海马缰核表达 ,阳性细胞主要有神经元 ,给药组比对照组表达明显增加。结论 :三七总皂甙可通过上调 b FGFR1的表达 ,从而促进脑出血后脑内神经元的存活及损伤修复。

Study the expression of FGFR-1 in brain after intracerebral hemorrhage and treatment effect of Panax notoginseng saponins.Immunohistochemistry technique has been used to examine the expression of bFGFR1 in rat brain in treatment group and control group after intracerebral hemorrhage.Result bFGFR1 immunoreactivity was found in neuron in cortex\,hippocampus\,habenular nucleus,and also surrounding hematoma.FGFR1 was enhanced in treatment group against control group.The expression of FGFR1 increased in frontal brain after intracerebral hemorrhage by Panax notoginseng saponins.