血管形成与膀胱癌分级及复发相关性研究

Study of the Relativity between MVD and Histopathological Grade and Recurrence in Transitional Cell Carcinoma of Bladder

目的 观察膀胱癌微血管密度 (MVD)及碱性成纤维细胞生长因子 (bFGF)与膀胱癌分级及复发的关系。方法 本组膀胱移行细胞癌患者 6 2例 ,年龄 36～ 82岁 ,平均 6 5岁。采用免疫组织化学染色CD34观察膀胱癌组织中MVD以及bFGF的表达情况。结果 G1级、G2级、G3膀胱癌中bFGF阳性率分别为 33.3%、4 8%、73.7% ,其中 ,G1级与G3级膀胱癌间差异有统计学意义 (P <0 .0 5 )。膀胱癌复发组及未复发组bFGF阳性率分别为 73.1%、36 .1%(P <0 .0 5 )。G1级、G2级、G3膀胱癌MDV分别为 4 4 .3± 11.6、5 3.5± 10 .6、71.9± 15 .3,G1级与G3级膀胱癌间差异有统计学意义 (P <0 .0 5 )。膀胱癌复发组及未复发组MDV分别为 4 1.7± 10 .9、77.2± 15 .3(P <0 .0 5 )。结论 膀胱癌bFGF表达及MVD与其分级及肿瘤复发相关 。

Objective To observe the relationship of MVD with histopathological grade and recurrence in transitional cell carcinoma of bladder(TCCB).Methods Observation was given to 62 patients with TCCB;CD34 and basic fibroblast growth factor(bFGF)were detected by immunohistochemical assay in tissues of TCCB and imcrovessel density(MVD)was analyzed by staining with antibodies to CD34.Results The positive rates of bFGF were 33.3%,48%,73.7% in tissues of G1,G2,G3,TCCB while those in tissues of primary group and recurrent group were 73.1% and 36.1%(P<0.05);the MVDs were 44.3±11.6,53.5±10.6,71.9±15.3 in tissues of G1,G2,G3,TCCB and those of primary group and recurrent group were 41.7±10.9,77.2±15.3(P<0.05).Conclusion This study indicates that MVD and bFGF are closely related to the histopathological grade and recurrence of TCCB;MVD has prognostic value on TCCB