抗哮喘新药齐留通的合成

Synthesis of zileuton,an anti-asthmatic drug

目的:合成抗哮喘新药齐留通。方法:以2-乙酰基苯并噻吩为起始原料,经3步反应合成齐留通。结果:目标化合物经~1H-NMR,^(13)C-NMR,FT-IR 和MS 确证其结构,HPLC 纯度在99.0%以上。结论:本方法原料易得,操作简便,总收率达50%。

Objective:To synthesize a novel anti-asthmatic drug zileuton.Methods:Zileuton wassynthesized via 3-step reactions with 2-acetyl benzo[b]thiophene as the starting material.Results:Thestructure of zileuton was verified by ~1H-NMR,^(13)C-NMR,FT-IR and MS.The purity of zileuton deter-mined by HPLC was higher than 99.0%.Conclusion:The simple and new synthetic process may ob-tain the total yield of 50%.