灵芝多糖拮抗环孢素A,氢化可的松及抗肿瘤药的免疫抑制作用

Antagonistic effect of Ganoderma lucidum polysaccharides on the immunosuppressive response induced by ciclosporin A,hydrocortisone and antitumor agents

灵芝多糖在50,100和200μg·ml^1时可完全拮抗环孢素A,丝裂霉素C,氟尿嘧啶和阿糖胞苷对小鼠混合淋巴细胞反应(MLR)的轻度抑制(抑制50％以下)作用,部分拮抗氢化考的松对MLR的严重抑制(抑制50％以上)作用。

Ganoderma lucidum polysaccharides(50,100,200μg·ml-1)could completely antagonize the mild inhibition(less than 50%)of murine mixed lymphocyte reaction induced by ciclosporin A,mitomycin C,fluorouracil or cytarabine and partly do the serious inhibition(more than 50%)induced byhydrocortisone.