普鲁卡因在静脉复合麻醉中对颅内压的影响

Effect of Intravenous Procaine on Intracranial Presssure in Balance Anesthesia

２０例垂体瘤病人，均分两组。以硫喷妥钠和琥珀胆碱快速诱导，氟哌啶、芬太尼和潘库溴铵维持麻醉。在轻过度换气（维持ＥＴＣＯ２在４．０ｋＰａ）的条件下，观察组以０．７５ｍｇ·ｋｇ－１·ｍｉｎ－１的速度静脉滴注１％的普鲁卡因。１０例病人中，有４例脑脊液压力呈轻度降低，３例轻度升高，但皆在０．２７ｋＰａ（２ｍｍＨｇ）以内。平均脑脊液压保持稳定，未出现有统计学意义的变化（Ｐ＞０．０５）。结果表明，在此模式的麻醉条件下，静脉滴注普鲁卡因对于颅内压井无显著影响。合理使用，不失为一好的神经外科麻醉用药。

Twenty cases with pituitary tumor were eqally divided into two groups,group I for intravenous procaine andgroup Ⅱ as control.All cases were induced by thiopental and succinylcholine and maintained with Innovar and pan-curonium. Under light hyperventilation(ETCO2=4.0kPa)1%procaine was infused intravenously at a rate of0.75mg/kg/min in group Ⅰ,cerebro-spinal fluid pressure(CSFP)was measured before surgery.The pressure re-duced in four cases and increased in three patients less than 2 torrs. The mean CSFP of this group was not changedsignificantly(P>0.05).The result suggests that in this model of anesthesia,intravenous procaine does not influ-ence on intracanial pressure noticeably. It is concluded that procaine infusion can be used if the basic rules of neuro-surgical anesthesia are followed strictly.