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糖尿病大鼠肾组织中单核细胞趋化蛋白-1的表达及意义 被引量：2

Significance of monocyte chemotactic peptide-1 expression in diabetes in rats
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摘要 目的:探讨单核细胞趋化蛋白-1(MCP鄄1)在糖尿病大鼠肾组织中的表达及其意义。方法:用链脲佐菌素制备糖尿病大鼠模型。采用免疫组化及多媒体彩色病理图文分析系统观察肾小球及肾小管中MCP鄄1的表达。结果:糖尿病大鼠肾小球及肾小管中MCP鄄1的表达显著上调。结论:MCP鄄1在糖尿病肾病发病机制中发挥重要作用。 Objective:To investigate the expression of monocyte chemotactic peptide-1(MCP-1) and their significance in the diabetes in rats. Methods:The model of diabetes was induced by streptozotocin. Immunohistochemical studies and media mix imaging analysis system were performed to detect the expression of MCP-1 on samples from rat kidney including the control group. Results: Significant up-regulation of MCP-1 expression was observed in the tubular cells and glomerulus in diabetes rats. Conclusion:The MCP-1 may play a pivotal pathogenic role in diabetic nephropathy.
作者 陆卫平 胡长军 吴曼青 赵云峰
机构地区 南京医科大学附属淮安第一医院内分泌科 南京医科大学小儿肾脏病研究中心
出处 《南京医科大学学报（自然科学版）》 CAS CSCD 北大核心 2005年第4期246-248,F002,共4页 Journal of Nanjing Medical University(Natural Sciences)
关键词 单核细胞趋化蛋白-1 糖尿病 糖尿病肾病 monocyte chemotactic peptide-1 diabetes diabetic nephropathy
分类号 R587.1 [医药卫生—内分泌]
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参考文献6

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共引文献5

同被引文献23

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引证文献2

二级引证文献6

南京医科大学学报（自然科学版）
2005年 第4期

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