摘要
目的观察大鼠严重烫伤早期血清白细胞介素6(IL6)的动态变化及丹参的治疗作用。方法建立30%Ⅲ度烫伤模型,88只Wistar大鼠随机分为正常对照组(A组,8只)、平衡液复苏组(B组,40只)和丹参治疗组(C组,40只)。B、C两组烫伤后立即按Parkland公式腹腔注射平衡液120ml/kg,C组在同样治疗的基础上腹腔注射丹参注射液3ml/kg,B、C两组分别于伤后3、6、12、24、48h检测血清IL6的含量。结果①与对照组相比较,复苏组血清IL6的含量在伤后3h即明显高于对照组,伤后12h达高峰,伤后48h仍高于保持在较高水平。②丹参治疗组在各相应时相点与对应的复苏组比较,两者的变化趋势基本一致,但血清IL6水平均低于复苏组,伤后3h起显著低于复苏组。结论严重烫伤早期血清IL6即明显升高;丹参注射液可通过降低血清IL6而行使其增强免疫功能的药理作用。
Objective To investigate the dynamical change of serum Interleukin-6(IL-6) level and the effect of salvia miltiorrhizae. Methods 88 Wistar rats were randomly divided into three groups: normal control group(group A), burn group (group B), and burn plus salvia miltior rhizae group(group C). Rats of group B and C received a 30% Ⅲ-degree burn and wer e resuscitated immediately with lactated Ringer solution (120 ml/kg). Additio nly, rats of group Creceived salvia miltiorrhizae at a dose of 3 ml/kg. The serum level of interleukin-6 was measured at 3, 6, 12, 24, 48 h after burn. Results ①In group B, serum IL-6 increased remarkably at 3 h after burn and reached the top at 12 h and still remained a high level at 48 h postburn . ② The change trendancy of serum IL-6 level in group C was similar to that in group B. In comparison with group B, the serum level of IL-6 level in group C was much lower. Conclusion The serum level of Interleu kin-6 increased immediatedly after burn and salvia miltiorrhizae had an immunit y enhancing effect by decreasing the serum level of Interleukin-6.
出处
《安徽医科大学学报》
CAS
北大核心
2005年第3期229-230,254,共3页
Acta Universitatis Medicinalis Anhui
