俞氏内异方组治疗子宫内膜异位症临床研究

Effect of Yu’s Neiyi recipe on endometriosis

目的了解俞氏内异方组治疗子宫内膜异位症(内异症)的临床疗效和可能的作用机制。方法48例内异症患者以益气补肾化瘀为主的水煎内服方、灌肠方及外敷方治疗,观察治疗前后临床症状、体征、基础体温(BBT)、血激素水平的变化及不育者的效果。结果内异症48例治疗有效率为94%,其中20例不育患者妊娠15例,妊娠率为75%。治疗后痛经积分及非经期盆腔痛积分显著降低(P<0.01),卵巢内膜样囊肿明显缩小(P<0.01),BBT类型分布及HPS(highphasescore)评分都有明显好转(P<0.01),血清泌乳素(PRL)水平明显下降(P<0.05),黄体生成素(LH)、雌二醇(E2)水平显著上升(P<0.05)。结论俞氏内异方组可显著改善内异症患者的症状和体征,改善患者的卵巢功能,促进不育者妊娠。

Objective: To investigate the effect of Yu’s Neiyi recipe on endometriosis.Methods: Yu’s Neiyi recipe was administered in 48 patients with endometriosis (including 20 cases of associated infertility). The clinical data, sonography, basal body temperature (BBT) and hormones levels were observed before and 3 months after the treatment. The pregnancy outcome was followed up within 2 years.Results: Efficacy of Yu’s Neiyi recipe in 48 patients was 93.75% within 3 months of treatment, and the pregnancy rate was 75% in 20 infertile patients. After the treatment, scores of both dysmenorrhea and chronic pelvic pain were significantly reduced (P<0.01, respectively), the size of ovarian endometrial cysts obviously decreased (P<0.01), and the BBT type and high phase score also significantly improved (P<0.01). During the herbal treatment, the high serum levels of PRL were significantly reduced (P< 0.05), and serum levels of LH and E_2 significantly increased (P<0.05).Conclusion: Yu’s Neiyi recipe not only significantly relieves the symptoms and signs of patients with endometriosis, but also shows a good regulation on patients’ovarian function to improve the pregnancy rate.