急性颅脑损伤患者血清NO、NOS和CNP测定的临床意义

Clinical Significance of Determination of Plasma C-type Natriuretic Peptide(CNP) and Serum NO, NOS Levels in Patients with Acute Brain Injury

目的:探讨了NO、NOS和血浆C-型利钠多肽(CNP)水平在急性颅脑损伤早期的病理、生理作用。方法:分别应用放免法测定血浆CNP水平,生化法测定NO、NOS水平。结果:在治疗前急性颅脑损伤患者血浆CNP水平和NO水平非常显著地低于正常人组水平(P<0.01),而NOS水平显著地高于正常人组水平(P<0.01),经治疗后一个月则与正常人组比较无显著性差异(P>0.05)。结论:观察血浆CNP、NO和NOS水平的变化对研究急性早期颅脑损伤的病理生理变化,判断疗效及预后观察是具有十分重要的临床意义。

Objective To investigate the clinical significance of changes of plasma CNP and serum NO, NOS levels in patients with acute brain injury at early stage and one month later. Methods Radioimmunoassay was used for determining plasma CNP concentration and biochemistry method for serum NO, NOS levels in 30 controls and 32 patients with acute brain injury at admission and one month later. Results Before treatment plasma CNP and serum NO levels in the patients were significantly lower and serum NOS levels significantly higher than those in controls (P<0.01, P<0.01). After treatment for one month, the levels were approaching normal (P>0.05). Conclusion Plasma CNP and serum NO, NOS levels were related to the pathophysiological process of acute brain injury and might be taken as indicator of the severity of the diseases.