中医药治疗视网膜色素变性的振荡电位研究

Oscillatory Potentials in Retinitis Pigmentosa with TCM Treatment

应用计算机平均技术，对５４例视网膜色素变性（ＲＰ）患者进行中医药治疗前后的视网膜振荡电位（ＯＰｓ）检测研究。结果表明：中医药治疗对各遗传分型及中医临床辨证分型ＲＰ病例的ΣＯＰｓ振幅有一定程度的改善，代表视锥成分的ＯＰ２子波振幅具有较明显的改善，而代表视杆成分的ＯＰ３子波振幅仅在视网膜病变轻、病程较短的病例中得以改善。可记录到ＯＰｓ波形的ＲＰ病例较治疗前增加了５例。提示中医药治疗可以有效地改善ＲＰ患者视网膜内层的循环状态，促进其神经突触活动，增强视细胞活性，对延缓病情进展具有特定的临床意义。

Computer-averaged oscillatory potentials(OPs)of electroretinogram(ERG)were recorded in 54 patients affected by different hereditary forms of retinitis pigmentosa(RP)before and after three-months of traditional Chinese medicins (TCM).This study was conducted in order to investigate the alterations of physiological function in inner part of the retina affected by RP. The results showed that OP waveforms were recordable in 22 and 27 patients before and after TCM treatment,respectively.The amplitudes of summed OPs(ΣOPs)were increased significantly in patients with different hereditary n1odes of RP, and also in those by clinical TCM classification after the treatment.The component-specific amplitudes of OPs were observed.In particular, OP2 showed an elevation in both dominant and nondominant patient groups, while OP3 only showed an elevation in the dominant group. The results suggest that OP2, which represents mainly cone OP activity, could be improved in the patients extensively;and OP3,which represents mainly rod OP activity,could be improved only in the patients with less advanced retinal degeneration.These data provide evidence that visual function in the inner retina of patient with RP could be improved to a cerTania extent with TCM treatment.