真菌Aspergillus fumigatus var .fumigatus的次生代谢产物(英文)

Secondary Metabolites of Aspergillus fumigatus var. fumigatus

目的:研究西双版纳粗榧共生真菌Aspergillus fumigatusvar .fumigatus的次生代谢产物。方法:通过柱层析法分离发酵产物的化学成分,并利用波谱数据和文献数据对照鉴定化合物的结构。结果:分离到2个化合物,分别鉴定为trypacidin (1)及其衍生物1 ,2-seco-trypacidin (2)。结论:化合物2是新结构;并对文献中关于trypacidin的C-4和C-7a位碳谱数据的指定进行了更正。

AIM： To study the secondary metabolites of the commensal microorganism （Aspergillus fumigatus var. fumigatus） of Cephalotaxus mannii. METHOD： Chemical constituents were isolated by column chromatography and structures were elucidated based on spectral analysis. RESULT： Two compounds were purified from the fermented extracts and identified to be trypacidin （1） and 1,2-seco-trypacidin （2）, respectively. CONCLUSION： Compound 2 is a new compound, and the 13C NMR assignments for the C-4 and C-7a of trypacidin were revised based on HMQC and HMBC experiments.