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榛花的降血糖作用及其机理的实验研究 被引量:17

The Effects and Mechanisms of Hazel's Flower on Decreasing Blood Sugar
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摘要 目的:观察榛花的降血糖作用并初步阐明其作用机理。方法:采用四氧嘧啶制作实验性糖尿病小鼠模型,以比色分析法测定血糖、血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量并观察肝糖原和胰岛B细胞。结果:榛花可降低实验性糖尿病小鼠的血糖水平,提高血清SOD活性并降低血清MDA含量,提高肝糖原含量,而未能使胰岛B细胞修复和再生。结论:榛花具有降低实验性糖尿病小鼠高血糖的作用,而这种作用可能是通过促进肝组织糖原合成等类胰岛素样作用和清除自由基及抗脂质过氧化过程实现的。 Objective:To observe the effects of Hazel's flower on decreasing blood sugar and clarify its mechanisms. Methods:By the experimental mouse model of diabetes induced by alloxan, by the methods of control, the blood sugar, activity of superoxide dismutase (SOD) of serum, amount of malondialdehyde (MDA) of serum were measured and hepatic glycogen and pancreas islet B cell were observed . Results: The Hazel's flower decreased the level of the blood sugar and the amount of MDA, and increased the activity of SOD and the contents of hepatic glycogen, but did not make the pancreas islet B cell repaired and regenerate. Conclusion :The Hazel's flower had the effect of decreasig blood sugar on diabetic mouse induced by alloxan. Its mechanism of decreasing blood sugar may be the insulin kind function of promoting synthesis of hepatic glycogen etc, clearancing free radicals and process of anti-lipid peroxidation.
出处 《时珍国医国药》 CAS CSCD 北大核心 2005年第11期1085-1087,共3页 Lishizhen Medicine and Materia Medica Research
关键词 榛花 降血糖 超氧化物歧化酶 丙二醛 组织化学 免疫组织化学 Hazel's flower Decrease blood sugar SOD MDA Histochemistry Immunohistochemistry
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  • 1陈双厚,中药药理与临床,1992年,8卷,特集,113页
  • 2王筠默,中草药,1989年,17卷,2期,19页
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  • 4高彦彬,吕仁和.中医药辨治糖尿病概述[J]中医杂志,1988(08).

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