奥沙利铂联合亚叶酸钙和氟尿嘧啶治疗晚期大肠癌的临床观察

Clinical study of Oxaliplatin Combined with 5-FU/CF in the treatment of patients with advanced colorectal carcinoma

目的观察奥沙利铂(OXA)联合亚叶酸钙(CF)、氟尿嘧啶(5-FU)治疗晚期大肠癌的近期疗效和毒副作用。方法33例患者均接受奥沙利铂130mg/m2+5%葡萄糖注射液500ml静脉滴注3小时,第1天;CF200mg/m2+5%葡萄糖注射液250ml静脉滴注2小时,给予5-FU400mg/m2静脉推注,后续5-FU600mg/m2静脉持续输注约48小时。21天为1周期,至少应用3周期后判定疗效。结果可评价疗效者30例,完全缓解(CR)3例,部分缓解(PR)11例,总有效率为46.7%。可评价毒性患者33例,骨髓抑制为主要毒副作用,白细胞下降达90.9%;其次为胃肠道反应,恶心呕吐发生率87.4%,腹泻则为45.5%;另外周围神经毒性高达51.5%。结论OXA联合CF+5-FU治疗晚期大肠癌有较好疗效,毒性反应轻可耐受,值得在临床上进一步推广。

Objective：to evaluate the efficacy and adverse effects of oxaliplatin combined with 5-fluorouracil/calcium folinate in the treatment of patients with advanced colorectal carcinoma. Methods ： Oxaliplatin 130mg/m^2 iv infusion for 3h d1, CF 200mg/m^2 iv infusion for 2h followed by 5-FU 300mg/m^2 iv bolus and 5-FU 600mg/m^2 iv infusion for 48h repeated every 3 weeks. Tumor assessment was done afer 3 cycles. Results ：33 patients entered this study,30 cases were evaluable for efficacy：CR 3 cases, PR 11 cases, SD 12 cases,PD 4 cases. The overall response rate was 46. 7%. The main adverse effects were myelosuppression. Neutropenia was 90.9% ,nausea/vomiting 87.4%, diarrhea was 45.5%, neurosensory toxicity was 51.5%. Conclusion： This regimen of oxaliplatin combined with 5-FU/CF was more effective for the treatment of advanced colorectal carcinoma, the toxicity was mild and tolerable, which is worthy further clinical study.