期刊文献+

洋地黄毒甙体内抗肿瘤活性及其增效作用 被引量:4

Antitumor Activity of Digitoxin in Vivo and its Enhancing Effect
下载PDF
导出
摘要 目的探讨洋地黄毒甙(DT)体内抗肿瘤活性及时常用化疗药5-氟尿嘧啶(5-FU)和环磷酰胺(CTX)的增效作用。方法  应用小鼠移植性肿瘤模型,观察药物对小鼠生命延长率或肿瘤抑制率的影响。在可耐受的剂量(0.1mg/kg·d-1,ip)下治疗小鼠腹水瘤EAC,H22,P388及实体瘤S180,U14。结果  对腹水瘤无对抗作用,对实体瘤有一定抑制作用,抑瘤率分别为34.6%,35.1%。DT与5-FU(200mg/kg·d-1×1,ip)合用能显著提高5-FU对腹水瘤小鼠的生命延长率,分别达到59.3%,77.4%和93.2%;与轻度抑瘤作用剂量(20mg/kg·d-1×2,ip)的CTX合用,对实体瘤的抑瘤活性高于单独给药组,抑瘤率分别为78.8%,80.8%。结论 DT和5-FU或CTX合用具有增强疗效的作用,毒性无明显相加。 Objective To study antitumor activity of digitoxin(DT)in mice and its enhancing effects to commonly-used chemotherapeutic agents such as 5-fluorouracil( 5-FU)and cytoxan (CTX0. Methods At a tolerable dose level,DT was administrated singly or in combination with 5-FU or CTX to treat 5 types of transplanted murine tumors(ascitic tumors EAC,H22,P388 and solid tumors S180,U14),animal life span increase or tumor weight inhibition were observed. Results DT had no effect against the ascitic tumors, a certain inhibition on the growth of the solid tumors with inhibition rate of 34.6%,35.1% respectively. Combined with low dose of 5-FU(200 mg/kg·d-1×1,ip),DT can greatly enchance the life span of mice with ascitic tumors by 59.3%,77.4%,93.2% respectively.In combination with slight tumor-inhibitory dose of CTX(20 mg/kg·d-1/2,ip),the effect was much pronounced than that of independent administration, giving inhibition rate of 79.8%,80.8% respectively.Conclusion The antitumor effect was significantly potentiated by combining DT with 5-FU or CTX,but their toxicities were not obviouslv enhanced.
出处 《福建医学院学报》 1996年第2期113-116,共4页
关键词 洋地黄毒甙 抗肿瘤活性 小鼠移植性肿瘤 增效作用 digitoxin antitumor activity transplanted tumors in mice enhancing effect
  • 相关文献

同被引文献21

  • 1王本祥,刘爱晶,崔景朝.人参茎叶和花皂甙抗肿瘤作用的研究[J].中成药,1989,11(2):27-29. 被引量:17
  • 2马云鹏,吴友仁.金E与肿瘤细胞DNA作用模式的探讨[J].中华肿瘤杂志,1989,11(2):95-97. 被引量:11
  • 3俞昌喜,林心建,黄自强,章雄文,吴国土.强心甙类药对长春新碱抗肿瘤活性的协同作用[J].福建医学院学报,1996,30(4):306-309. 被引量:2
  • 4陈瑞婷 花泽.三尖杉酯碱和高三尖杉酯碱类的药理研究[J].科学通报,1980,18(5):859-861.
  • 5杨医亚 刘德傅.中医学 [M].北京:人民卫生出版社,1983.109-215.
  • 6常敏毅.抗癌中药 [M].长沙:湖南科学技术出版社,1998.11-58.
  • 7胥彬 杨金龙.抗肿瘤药物羟基喜树碱[J].医药工业,1985,16(2):22-22.
  • 8Jiang F, Chopp M, Katakowski M, et al. Photodynamic therapy with photofrin reduces invasiveness of malignant human glioma cells[J]. Lasers Med Sci, 2002, 17(4):280~288.
  • 9Duska LR, Hamblin MR, Miller J, et al. Combination photoimmunotherapy and cisplatin: effects on human ovarian cancer ex vivo[J]. J Natl Cancer Inst, 1999, 91 (18):1557~1563.
  • 10Gulliya KS, Chanh T, Newman J, et al. Preactivation-a novel antitumour and antiviral approach [J]. EurJ Cancer, 1990, 26(5):551 ~553.

引证文献4

二级引证文献26

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部