Serum soluble interleukin-2 receptor levels in patients with chronic hepatitis B virus infection and its relation with antiHBc

AIM： To investigate the relationship between serum soluble interleukin-2 receptor （sIL-2R） level and anti-HBc in patients with chronic hepatitis B virus （HBV） infection. METHODS： Sera from 100 patients with chronic HBV infection and 30 healthy controls were included in this study. The patients were divided into group A [HBsAg （＋）, HBeAg （＋） and anti-HBc （＋）, n = 50] and group B [HBsAg （＋）, HBeAg （＋） and anti-HBc （-）, n = 50]. sIL-2R levels were determined using ELISA. HBV DNA and alanine aminotransferase （ALT） were also detected. RESULTS： Serum sIL-2R levels were significantly higher in patients with chronic HBV infection than in healthy controls. Moreover, serum sIL-2R levels were significantly higher in patients with HBsAg （＋）, HBeAg （＋） and antiHBc （＋） （976.56±213.51×10^3 U/L） than in patients with HBsAg （＋）, HBeAg （＋） and anti-HBc （-） （393.41±189.54 ×10^3 U/L, P〈 0.01）. A significant relationship was found between serum sIL-2R and ALT levels （P〈 0.01） in patients with chronic HBV infection, but there was no correlation between sIL-2R and HBV DNA levels. The anti-HBc status was significantly related to the age of patients （P〈 0.01）. CONCLUSION： The high sIL-2R level is related to positive anti-HBc in chronic hepatitis B patients. Positive anti-HBc may be related to T-lymphocyte activation and negative anti-HBc may imply immune tolerance in these patients.

瞄准：与长期的肝炎 B (HBV ) 感染在病人调查在可溶的 interleukin-2 受体(sIL-2R ) 铺平的浆液和 anti-HBc 之间的关系。方法：从有长期的 HBV 感染和 30 健康控制的 100 个病人的血清在这研究被包括。病人被划分成组 A [HBsAg (+) ， HBeAg (+) 和 anti-HBc (+) ， n=50 ] 并且组 B [HBsAg (+) ， HBeAg (+) 和 anti-HBc (-) ， n=50 ] 。sIL-2R 层次用 ELISA 被决定。HBV DNA 和丙氨酸 aminotransferase (中高音) 也被检测。结果：浆液 sIL-2R 层次比在健康控制在有长期的 HBV 感染的病人是显著地更高的。而且，浆液 sIL-2R 层次在有比在有 HBsAg (+) ， HBeAg (+) 和 anti-HBc (-) 的病人的 HBsAg (+) ， HBeAg (+) 和 anti-HBc (+)(976.56+/-213.51x10 (3 ) U/L ) 的病人是显著地更高的(393.41+/-189.54x10 (3 ) U/L， P<0.01 ) 。一种重要关系与长期的 HBV 感染在病人在浆液 sIL-2R 和中高音层次(P<0.01 ) 之间被发现，但是在 sIL-2R 和 HBV DNA 层次之间没有关联。anti-HBc 地位是显著地与病人(P<0.01 ) 的年龄有关。结论：高 sIL-2R 水平与在长期的肝炎 B 病人的积极 anti-HBc 有关。积极 anti-HBc 可能与 T 淋巴细胞激活有关，否定 anti-HBc 可以在这些病人暗示有免疫力的忍耐。