摘要
目的:介绍群体药代动力学模型在抗生素调整剂量上的应用。方法:群体药代动力学模型以及药代动力学(PK)-药效动力学(PD)模型的基本概念、建立步骤、应用特点以及国内外发展现状。并通过两个举例说明剂量调试方法。结果与结论:群体药代动力学和TDM监测紧密联系用于临床抗感染治疗,PK-PD模型的应用有利于临床药学的剂量设计和剂量调整,为不同患者群体的抗感染治疗的最合理解释。
OBJECTIVE： To introduce the application of population pharmacokinetic model to dose - adjustment of antibiotics. METHODS： To analyze basic concepts of population pharmacokinetic model and pharmacokinetic （PK） - pharmacodynamic（PD） model, set up the procedure and study applicational characters and development status at home and abroad, two examples were given for explaining dose - adjustment method. RESULTS＆CONCLUSION： Close combination of population pharmacokinetics and therapeutic drug monitoring can be applied to anti - infective therapy in the clinic. The use of PK- PD model will be beneficial to dose design and adjustment in clinical pharmacy, it will also make most rational explanations for different patient population in anti - infective therapy.
出处
《中国医院用药评价与分析》
2006年第1期49-52,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
