鼻咽癌放疗后生育后代健康状况调查

The investigation on the health condition of descendants come of patients with nasopharyngeal carcinoma after radiotherapy

目的对鼻咽癌患者康复后生育的后代健康发育情况进行调查,评价鼻咽癌治疗对后代健康发育情况的影响,指导提高鼻咽癌患者康复期的生活质量。方法选取1969年至1997年间放疗后可能有生育能力的鼻咽癌患者,女性≤35岁,男性≤45岁,随机抽取120例发放自行设计的《鼻咽癌放疗后生育的后代健康状况调查表》,采用电话、信件、上门随访方法,对治疗后生育的后代健康发育情况进行调查。结果有24例患者经治疗后再生育,其中男性17例,女性7例;治疗时最大年龄37岁,最小年龄16岁;治疗后最短在1年后生育,最长在6年后生育;总共生育45胎,男性19胎,女性26胎;目前最小年龄3岁,最大年龄33岁;全部体格发育正常,智力正常,学习成绩从一般～优秀。结论鼻咽癌患者治疗后生育的后代体格发育正常,智力正常,提示健康,这与放疗防护最优化设计进步相关,使辐射伤害降到最低。

Objective To investigate the health and developmental condition of the descendants come of patients with nasopharyngeal carcinoma after radiotherapy in order to provid the scientific information and reduce the universal anxiety and improve the quality of life of convalescence stage. Methods To randomly select 120 patients （female ≤35 years old, Male ≤45 years old ） who had the potential generation after radiotherapy,to distribute the self-design questionaire of The health and developmental condition of the descendants who come of the patients with nasopharyngeal carcinoma after radiotherapy, and to analyse and sommarize the information by telephone, postal delivery and follow-up visit. Results There were 24 patients （Male 17 cases, female 7 cases） who had the potential generation after radiotherapy, the oldest case was 37 years old, and the youngest case was 16 years old, the shortest procreative period was 1 year after radiotherapy, the longest procreative period was 6 years after radiotherapy, there were 45 descendants who come of the patients, the descendants included male 19 cases, female 26 cases, the youngest child was 3 years old and the oldest case was 33 years old, all the descendants had normal intelligence and development, the performance record was from common to superiority. Conclusion The descendants who come of the patients with nasopharyngeal carcinoma after radiotherapy have normal intelligence and development, radiotherapy does not affect the potential generation, but the relativity between radiotherapy and potential generation needs an ulterior research.