摘要
AIM： To investigate the therapeutic effects of resveratrol （RESV） as a free radical scavenger on experimental severe acute pancreatitis （SAP）. METHODS： Seventy-two male Sprague-Dawley rats were divided randomly into sham operation group, SAP group, and resveratrol-treated group. Pancreatitis was induced by intraductal administration of 0.1 mL/kg 4% sodium taurocholate. RESV was given intravenously at a dose of 20 mg/kg body weight. All animals were killed at 3, 6, 12 h after induction of the model. Serum amylase, pancreatic superoxide dismutase （SOD）, malondialdehyde （MDA）, and myeloperoxidase （MPO） were determined. Pathologic changes of the pancreas were observed under optical microscope. RESULTS： The serum amylase, pancreatic MPO and the score of pathologic damage increased after the induction of pancreatitis, early （3, 6 h） SAP samples were characterized by decreased pancreatic SOD and increased pancreatic MDA. Resveratrol exhibited a protective effect against lipid peroxidation in cell membrane caused by oxygen free radicals in the early stage of SAP. This attenuation of the redox state impairment reduced cellular oxidative damage, as reflected by lower serum amylase, less severe pancreatic lesions, normal pancreatic MDA levels, as well as diminished neutrophil infiltration in pancreas. CONCLUSION： RESV may exert its therapeutic effect on SAP by lowering pancreatic oxidative free radicals and reducing pancreatic tissue infiltration of neutrophils.
瞄准：在试验性的严重尖锐胰腺炎(树液) 上作为自由基 scavenger 调查 resveratrol (RESV ) 的治疗学的效果。方法：72 只男 Sprague-Dawley 老鼠随机被划分成假冒的操作组，树液组，和对待 resveratrol 的组。胰腺炎被 0.1 mL/kg 的管内管理导致 4% 牛磺胆酸钠。RESV 在 20 mg/kg 体重的剂量静脉内地被给。所有动物在 3 点被打死， 6，在模型的正式就职以后的 12 h。浆液淀粉酶，胰腺的超级氧化物歧化酶(草皮) ， malondialdehyde (MDA ) ，和 myeloperoxidase (军邮局) 是坚定的。胰的病理学的变化在光显微镜下面被观察。结果：浆液淀粉酶，胰腺的军邮局和病理学的损坏的分数在胰腺炎的正式就职以后增加了，早(3， 6 h ) 树液样品被减少的胰腺的草皮描绘并且增加了胰腺的 MDA。Resveratrol 在氧自由基在树液的早阶段引起的房间膜每氧化对类脂化合物展出了保护的效果。氧化还原作用状态缺陷的这变细减少了细胞的氧化损坏，由更低的浆液淀粉酶思考了不太严重的胰腺的损害，正常胰腺的 MDA 层次，以及在胰的减少的嗜中性的渗入。结论：RESV 可以由降低胰腺的氧化自由基并且减少 neutrophils 的胰腺的织物渗入在树液上施加它的治疗学的效果。
