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D3S1289、D5S406、D6S277微卫星不稳定性与子宫颈癌的相关性

A Study of Microsatellite Instability in Cervical Cancer
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摘要 目的:探讨微卫星不稳定性(m icrosatellite instab ility,M I)与子宫颈癌的相关性。方法:22例子宫颈浸润性鳞癌石蜡标本,选取3、5和6号染色体上的3个微卫星位点D3S1289、D5S406、D6S277进行M I分析。结果:在子宫颈癌标本中3个位点均未发现M I和杂合性缺失(LOH)的改变。结论:3个微卫星位点未见M I和LOH的改变,可能与病例少、位点少、种族及取样有关。 Objective: To investigate microsatellite instability (MI) in cervical cancer. Methods: MI of 3 microsatellite markers were detected in 22 invasive squamous cancers and self normal cervix. Results : MI and loss of heterozygosity ( LOH ) were not detected in D3S1289,D5S406, D6S2773 in 22 cervical cancers. Conclusions: The results of MI analysis were negative, may be related with less cases and microsatellite markers,races and clinician- collected cervical samples.
作者 石淑贤 耿力
出处 《包头医学院学报》 CAS 2006年第1期4-5,共2页 Journal of Baotou Medical College
关键词 子宫颈癌 微卫星不稳定性 Cervical cancer Microsatellite instability
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