4-氨基吡啶合成过程的绿色评价

Green Evaluation of Different Preparation Processes of 4-aminopyridine

采用原子利用率、环境因子和环境商以及GREENSCOPE法对4-氨基吡啶的不同合成工艺过程进行了绿色评价.与传统的铁粉还原和催化氢化过程相比,电化学还原方法具有明显的优势:工艺操作简单,反应收率高,生产成本低,具有环境友好和可持续性.采用电化学方法还原硝基化合物制备氨基化合物符合绿色化学发展的趋势,满足可持续发展要求,在精细化工领域具有良好的应用前景.

The green evaluation of different synthesis technologies for preparing 4-aminopyridine was carried out by means of atom utilization efficiency, environment factor and environment quotient and GREENSCOPE methods. Contrasted with the traditional processes such as iron powder reduction and catalytic hydrogenation, the electro-reduction technology has some evident advantages, which can be characterized as simple process, high yield, low production cost, benignity to environment and well sustainable development. The electrochemical technology for reduction of nitro compounds to corresponding amines meets with the trend of green chemistry and the demand of sustainable development, and will have a promising prospect in fine chemical field.