伪麻那敏渗透泵的药物动力学

Pharmacokinetics of pseudophedrine and chlorpheniramine maleate osmotic pump

目的建立一种同时测定动物血浆中盐酸伪麻黄碱和马来酸氯苯那敏方法,并进行伪麻那敏渗透泵的药物动力学研究。方法8只Beagle犬单次口服伪麻那敏渗透泵2片,用LC MS法测定血浆中各药物浓度,计算2种药物的药物动力学参数。结果单次口服伪麻那敏渗透泵2片后的主要药物动力学参数:盐酸伪麻黄碱t1/2为(3.36±1.05)h,tmax为(5.75±1.49)h,ρmax为(1110.86±200.61)μg.L-1,AUC0-t为(10 755.43±3 274.35)μg.h.L-1,马来酸氯苯那敏t1/2为(5.01±2.91)h,tmax为(4.06±1.70)h,ρmax为(5.02±1.81)μg.L-1,AUC0-t为(34.71±22.15)μg.h.L-1。结论本方法能测定口服伪麻那敏渗透泵的血药质量浓度,进行动物药物动力学研究。

Objectives To investigate pharmacokinetics of pseudoephedrine and chlorpheniramine maleate in dogs and establish a method for the simultaneous determination of plasma pseudophedrineland chlorpheniramine maleate. Methods 8 Beagle dogs were orally administered a single dose of pseudoephedrine hydrochloride and chlorpheniramine maleate osmotic pump（2tablets）. The plasma concentrations were determined by LC-MS. The pharmacokinetics parameters of the two drugs of the test preparation were caculated. Results The pharmacokinetics parameters of pseudophedrine and chlorpheniramine maleate were as follows： t1/2（3.36 ± 1.05） h and （5.01 ± 2.91） h; tmax（5.75 ± 1.49） h and （4.06± 1.70） h; pmax（1110. 86 ± 200.61） μg·L^-1 and （5.02± 1.81） μg· L^-1;AUC0.t（10 755.43 ± 3274.35） μg·h· L^-1 and （34.71 ± 22.15） μg· h· L^-1. Conclusions This method is simple , rapid, sensitive and accurate and can be used for investigating the pharmacokinetics of pseudophedrine hydrochloride and chlorpheniramine maleate osmotic pump.