黄芪多糖对力竭小鼠保护作用及运动能力的影响

Protection action and the effect of sport's ability of Astraglaus polysaccharide in exhausted mice

目的探讨黄芪多糖对力竭小鼠保护作用及运动能力的影响。方法用50%的黄芪多糖溶液和生理盐水分别给实验组和对照组小鼠进行灌胃饲养15 d,然后,让两组小鼠游泳至力竭,记录游泳至力竭所持续的时间。迅速处死小鼠取出心、肝、肾组织,制备组织匀浆,测试其超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽过氧化物酶(GSH-Px)的含量。结果①黄芪多糖可以显著延长小鼠游泳至力竭的时间(P<0.001);②实验组小鼠心、肝、肾组织中MDA的含量显著低于对照组(P<0.001);③SOD的含量在肝、肾组织中显著高于对照组(P<0.001),在心组织中显著低于对照组(P<0.001);④实验组小鼠心、肝、肾组织中GSH-Px的含量显著高于对照组(P<0.001)。结论黄芪多糖能明显提高小鼠的运动能力以及抗力竭运动所导致的运动损伤的能力。

Objective To investigate the Protection action of Astragalus polysaccharide （APS） and its effect on exercise ability in exhausted mice. Methods The mice were randomized to receive 50% APS solution or 0.9% NS（ control group） orally for 15 days. Let the mice do exhaustive swimming exercise, the time they lasted was recorded. Then we executed the mice, took out the heart, liver and kidney immediately to prepare tissue homogenate for SOD, MDA and GSH - Px determination. Results ①APS significantly increased the time of exhaustive swimming exercise （ P 〈0. 010）②MDA content in APS group mice＇s heart, liver and kidney was significantly lower as compared with control group（ P 〈0.01 ） ;③ SOD content of APS group mice was significantly higher in liver and kidney tissue, but significantly lower in heart tissue compared with control group（ P 〈 0.01 ）. ④GSH - Px content of APS group mice was significantly higher than that of control group. Conclusion APS can significantly improve mice＇s exercise ability and increase mice＇s resistance to injury caused by exhausted exercise.