缬沙坦胶囊对老年高血压患者血管内皮功能的影响

Influence of valsarta capsule on the function of the vascular endothelium in elderly patients with hypertension

目的 探讨缬沙坦（valsarta）对血管内皮功能的影响以及对老年高血压（EH）的疗效.方法 64例EH患者（EH组）,给予缬沙坦治疗4周,剂量80～160 mg/d,60例健康老年人作为对照组，测量2组治疗前后血压及血浆一氧化氮（nitric oxide,NO）和内皮素（endothelin,ET-1）水平。结果 治疗前，EH组血浆NO浓度显著低于对照组（P＜0.01），而血浆ET-1浓度明显高于对照组（P＜0.01）；EH组血压变化与血浆NO浓度呈负相关而与ET-1浓度呈正相关.经缬沙坦治疗4周后,收缩压及舒张压均明显下降（P＜0.01）,但心率变化不显著（P＞0.05）,治疗总有效率为87.5%.治疗4周后血浆NO水平显著升高（P＜0.05）,且分级越高,血浆NO及ET-1浓度变化越显著。结论 缬沙坦有显著的降压疗效,可以显著修复和改善EH不良的血管内皮结构及功能.

Objective To investigate the influence of valsarta capsule on the function of vascular endothelium in elderly patients with hypertension and its therapeutic effect on senile hypertension. Methods 64 elderly hypertension （EH） patients were treated with valsarta for 4 weeks with the dose range from 80 to 160 mg/d and then compared with 60 healthy elderly people before and after treatment by measuring the levels of blood pressure, plasma nitric oxide and endothelin （ET-1）.Results The nitric oxide levels in EH group were significantly lower than those of control group （ P 〈 0.01）, while the levels of ET-1 were obviously higher than those of control group （ P 〈 0.01）. The change of blood pressure in EH group was negatively related with the levels of nitric oxide,however which was positively related with the levels of ET-1.After 4-week＇ treatment with valsarta, systolic and diastolic pressures in both groups remarkably decreased,as compared with those before treatment （ P 〈0.01） ,but their heart rates didn＇ t change significantly （ P 〉 0.06）,and the total effective rate was 87.5%. The nitric oxide levels were increased significantly （ P 〈0.05） ,and the higher the degree was,the more notable the change of nitric oxide levels and ET-1 levels became. Conclusion Valsarta is effective in treating hypertension, which may improve poor structure and function of vascular endothelium.