东紫苏根中抑菌活性成分的研究

Study on the Antifungal Components in the Root of Elsholtzia bodinieri Vaniot

采用生物活性跟踪法从东紫苏根中分离出3个具有广谱抑菌活性的物质,通过波谱分析并与文献值比较,分别鉴定为卢氏冬凌草素5(Ⅰ)、槲皮素(Ⅱ)和木犀草素(Ⅲ),其中化合物Ⅰ为首次从该属植物中分离得到.抑菌试验表明:3个化合物对枯草芽孢杆菌、金黄色葡萄球菌和大肠杆菌等有不同程度的抑菌和杀菌作用.

Three antimicrobial active components were isolated from the root of Elsholtzia bodinieri V. by bioactivity guided method. On the basis of spectral analysis and comparision with literature, their structures were identified as ludongnin 5 （ Ⅰ ）, quercetin （ Ⅱ ） and luteolin （Ⅲ ）, respectively. Among them, compound Ⅰ was obtained from Elsholtzia genus for the first time. The antimicrobial experiments indicated that compounds Ⅰ -Ⅲ showed the inhabitory and bactericidal activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli in varying degrees. The scientific foundations were provided more further to exploit and utilize this plant by the studying.