中医药治疗视网膜色素变性的闪烁光视网膜电图研究

Study on Treatment of Retinitis Pigmentosa with Traditional Chinese Medicine by Flicker Electroretinogram

采用改良的闪烁光视网膜电图（ＥＲＧ）记录与分析技术对经中医药治疗的视网膜色素变性（ＲＰ）５４例患者（１０６只眼）进行了研究。结果表明：（１）闪烁光ＥＲＧ在ＲＰ眼的检测远较ＥＲＧ的其它成分敏感，结合红光谱效果更佳；（２）各型ＲＰ眼的３０Ｈｚ闪烁指数与反应时间在治疗后发生不同程度的改善，在脾肾阳虚型和常染色体显性遗传ＲＰ的改变具有显著性意义（Ｐ＜０．０１）；（３）不同频率闪烁光反应相位角值在治疗后的降低亦具有统计学意义。从而提示中医药治疗可以有效地改善ＲＰ眼视网膜锥体系统功能，增进其神经网络的生物活性，对延缓病情进展，保持中心视力具有一定的临床意义。

Study on treatment of 54 patients(106 eyes) of retinitis pigmentosa(RP) with traditional Chinese medicine was conducted by using modified method of electroretinography. Results showed:(1)Flicker response of electroretinogram was the most sensitive criterion in examination,it was more effective when combined with infrared spectrogram.(27) The 30 Hz flicker index,response time were improved after TCM therapy in different hereditary types of RP,the improvement was significant in patients with Yang-Deficiency of Spleen-Kidney Syndrome and those of autosomal dominant inheritance type(P<0.01).(3) Decrease of phase angle under different frequency of flicker after treatment was also significant statistically.The results suggested that flicker responses,which represents mainly retinal cone activity of patients,could be improved to a certain extent by TCM treatment,even in those with advanced retinal degeneration.TCM treatment could also enhance the bioactivity of nerve network and therefore have a definite significance in retarding the progression of disease and keeping the central vision.The flicker ERG,especially its flicker index,is an effective, sensitive and useful parameter for detection of visual function in patient with retinitis pigmentosa.