期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

动脉粥样硬化兔血管血凝素样氧化型低密度脂蛋白受体1表达及雷米普利的干预作用 被引量：2

Effects of Ramipril on Expression of Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 in Rabbit Model of Atherosclerosis
下载PDF
导出
摘要 目的探讨血管紧张素转化酶抑制剂对动脉粥样硬化家兔血管血凝素样氧化型低密度脂蛋白受体1表达的影响。方法以家兔动脉粥样硬化模型为研究对象,采用免疫组织化学和逆转录聚合酶链反应方法评价动脉粥样硬化家兔血管血凝素样氧化型低密度脂蛋白受体1蛋白和信使核糖核酸表达及口服雷米普利的干预效应。结果高脂组血管血凝素样氧化型低密度脂蛋白受体1蛋白和信使核糖核酸表达均显著增加,雷米普利组血管血凝素样氧化型低密度脂蛋白受体1蛋白和信使核糖核酸表达水平较高脂组显著下降(P均<0.05)。结论结果提示,服用雷米普利可明显抑制动脉粥样硬化病变血管血凝素样氧化型低密度脂蛋白受体1蛋白和信使核糖核酸表达,从而可能在动脉粥样硬化的预防中起重要作用。 Aim To investigate the effects of Ramipril on expression of lectin-like oxidized low density hpoprotein receptor-1 （LOX-1） in a rabbit model of atherosclerosis. Methods Twenty-four male New Zealand white rabbits were randomly divided into three groups： normal diet group, hypercholesterol diet group and Ramipril-treated group. Expression of lectin-like oxidized low density lipoprotein receptor-1 in a rabbit model of atherosclerosis was detected by immunochemistry and reverse transcription polymerase chain reaction （RT-PCR）. Results Expression of LOX-1 in hypercholesterol group significantly increased compared with normal diet group. There was a significant dicrease in expression of LOX-1 in the Ramipril-treated group （P〈0.05）. Conclusion Ramipril inhibits vascular LOX-1 expression, which may play an important role in prevention of atherosclerosis.
作者 刘忠志 董波 刘同宝 许晓群 于永慧 刘莹
机构地区 山东大学山东省立医院 山东省医学科学院
出处 《中国动脉硬化杂志》 CAS CSCD 2006年第1期37-40,共4页 Chinese Journal of Arteriosclerosis
关键词 病理学与病理生理学 雷米普利对血管血凝素样氧化型低密度脂蛋白受体1表达的影响 免疫组织化学与逆转录聚合酶链反应 血凝素样氧化型低密度脂蛋白受体1 动脉粥样硬化 雷米普利 家兔 Atherosclerosis Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 Ramipril Rabbits Immunochemistry Reverse Transcription Polymerase Chain Reaction
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献11

  • 1Murase T,Kume N,Kataoka H,Minami M,Sawamura T,Masaki T.Identification of soluble forms of lectin-like oxidized LDL receptor-1[J].Arteriosclerosis Thromb Vasc Biol,2000,20 (3):715-720
  • 2Mehta JL,Li D.Identification,regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor[J].J Am Coll Cardiol,2002,39 (9):1 429-435
  • 3Li DY,Zhang YC,Philips MI,Sawamura T,Mehta JL.Upregulation of endothelial receptor for oxidized low-density lipoprotein receptor(LOX-1)in cultured human coronary artery endothelial cell by angiotensinⅡtypeⅠreceptor activation[J].Circ Res,1999,84 (9):1 043-049
  • 4Cilingiroglu M,Ozer K.The lectin-like oxidized low-density lipoprotein receptor and its role in atherosclerosis[J].Curr Atheroscler Rep,2005,7 (2):103-107
  • 5Shin HK,Kim YK,Kim KY,Lee JH,Hong KW.Remnant lipoprotein particles induce apoptosis in endothelial cell by NAD(P)H oxidase-mediated production of superoxide and cytokines via lectin-like oxidized low-density lipoprotein receptor-1 activation:prevention by cilostazol[J].Circulation,2004,109 (8):1 022-028
  • 6Maingrette F,Renier G.Linoleic acid increases lectin-like oxidized LDL receptor-1 (LOX-1)expression in human aortic endothelial cell[J].Diabetes,2005,54 (5):1 506-513
  • 7Li D,Saldeen T,Romeo F,Mehta JL.Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cell:the potential role of transcription factor NF-kappaB[J].Circulation,2000,102 (16):1 907-919
  • 8Li D,Singh RM,Liu L,Chen H,Singh BM,Kazzaz N,et al.Oxidized-LDL through LOX-1 increases the expression of angiotensin converting enzyme in human coronary artery endothelial cell[J].Cardiovasc Res,2003,57 (1):238-243
  • 9Rueckschloss U,Quim MT,Holtz J,Moraweitz H.Dose-dependent regulation of NAPDH oxidase expression by angiotensin Ⅱ in human endothelial cell:protective effect of angiotensin Ⅱ type 1 receptor blockade in patients with coronary artery disease[J].Arteriosclerosis Thromb Vasc Biol,2002,22 (11):1 845-851
  • 10Ruiz-Ortega M,Lorenzo O,Ruperez M,Esteban V,Suzuki Y,Mezzano S,et al.Role of rinin-angioten system in vascular disease[J].Hypertension,2001,38:1 382-387

同被引文献19

  • 1王燕,王炎,汪道文.苯扎贝特对牛主动脉内皮细胞一氧化氮合酶基因表达的影响及其机制的研究[J].中华心血管病杂志,2006,34(6):530-536. 被引量：8
  • 2Garahene V. The main determinants of endothelial dysfunction [ J ]. Medicine, 2006, 42 : 362-369.
  • 3Mehta JL, Li DY, Chen HJ, et al. Inhibition of LOX-1 by statins may relate to upregulation of eNOS [ J ]. Biochem Biophys Res Commun, 2001, 289 : 857-861.
  • 4Itabe H, Takano T. Oxidized low density lipoprotein: the occurrence and metabolism ineirculation and in foam cells [ J ]. J Atheroscler Thromb , 2000, 7 (3) : 123-131.
  • 5Hecke A, Brooks H, Schafer K, et al. Successful silencing of plasmino- gen activator inhibitor-1 in human vascular endothelial cells using small interfering RNA [J]. Thromb Haemost, 2006, 95 (5) : 857 -864.
  • 6Hayashi T, Juliet PA, Miyazaki A, et al. Beta antagonist and beta agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNF alpha in rat with type II diabetes [ J ]. Life Sci, 2007, 80 (6) : 592-599.
  • 7Cottone S, Mule G, Nardi E, et al. Microalbuminufia and early endothelial activation in essential hypertension [ J ]. J Hum Hypertens, 2007, 21 (2) : 167-172.
  • 8Arbel Y, Dvir D, Feinberg MS, et al. The association between fight coronary artery morphology and endothelial function [J]. lnt J Cardiol, 2007, 115 ( 1 ) : 19-23.
  • 9Chen JH, Chen HI, Wang JS. Effects of welsh onion extracts on human platelet function in vitro [ J ]. Life Sci, 2000, 66:1 571-579.
  • 10Reidenbach C, Schwinger RH, Steinritz D, et al Nebivolol induces eNOS activation and NO - liberation in murine corpus cavemosum [J]. Life Sci, 2007, 80:2 421-427.

引证文献2

二级引证文献6

中国动脉硬化杂志
2006年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部