不同年龄包茎和包皮过长患者包皮组织中触觉小体的观察

Observations on Meissner's corpuscle in prepuces of different ages

目的观察不同年龄包皮组织中触觉小体的变化规律。方法收集3～59岁包茎及包皮过长组织标本204例。免疫组化方法对标本中触觉小体进行染色,观察每例标本中触觉小体密度。应用卡方检验和线性回归方法分别对包茎和包皮过长触觉小体密度差异以及与年龄相关性进行统计学分析。结果包皮过长组织中触觉小体密度婴幼儿期以后渐增加,15岁达到最高,20岁前包茎和包皮过长组织中触觉小体密度无明显差异,其后,包皮过长组织呈下降趋势。包皮过长组织中触觉小体密度与年龄呈负相关关系(r=-0．236,P=0．009),包茎组织中触觉小体密度与年龄间虽呈正相关关系,但无统计学意义(r=0．193,P=0．084)。结论包皮过长组织中触觉小体密度与外生殖器发育成熟同步,并与成年男性性功能状态一致。成年包茎组织中触觉小体持续较高水平可能是一种生理性代偿。

Objective To observe Meissner＇ s corpuscles in prepuces of different shapes and ages. Methods The Meissner＇ s corpuscles were detected with immunohistochemical stain in 204 prepuce samples of different shapes and ages （3 -59 years） ,and the density of Meissner＇ s corpuscles in every sample was obtained as well. The difference of Meissner＇ s corpuscle densities between phimosis and redundant prepuce,and correlation between Meissner＇ s corpuscle densities and ages were analyzed with Chi-square test and linear regression,respectively. Results The density of Meissner＇ s corpuscles in redundant prepuce has begun to increase since infancy and reached the peak at the age about 15 years. No significant difference in densities of Meissner＇ s corpuscles between phimosis and redundant prepuce was observed till the age of 20 years,and then there was a trend of disappearance of Meissner＇ s corpuscles in redundant prepuce. A significantly negative correlation between the densities of Meissner＇ s corpuscles and ages was revealed in redundant prepuce （ r = - 0. 236, P = 0. 009） , whereas an insignificantly positive correlation between the densities of Meissner＇ s corpuscles and ages was shown in phimosis （ r = 0. 193 ,P = 0. 084）. Conclusions The densities of Meissner＇ s corpuscles in redundant prepuce develop synchronically with genital differentiation and accord with the status of sexual function in adult males. The persistent high level of Meissner＇ s corpuscles in adult phimosis might be a mechanism of physiological compensation.