摘要
目的探讨前愈煎剂治疗慢性前列腺炎的疗效与作用机制。方法用大肠埃希菌和角叉菜胶分别建立大鼠慢性细菌性前列腺炎(CBP)和非细菌性前列腺炎病理模型,分别用前愈煎剂和前列泰片进行对照治疗,观察以上两种药物对两种慢性前列腺炎模型局部免疫功能的影响,分别利用免疫放射法和酶联免疫吸附法(ELISA)检测大鼠前列腺分泌型免疫球蛋白(SIgA)和白细胞介素8(IL-8)水平。结果CBP模型前愈治疗组与CBP模型对照组比较,SIgA和IL-8水平均差异有显著性(均P<0.05);前愈煎剂治疗非细菌性前列腺炎模型组与非细菌性前列腺炎模型组比较,SIgA和IL-8水平均差异有显著性(均P<0.05)。结论前愈煎剂能显著调节慢性前列腺炎大鼠前列腺局部免疫功能,减轻病变前列腺间质炎症反应,促进病损修复作用,调节前列腺局部免疫功能的作用与其治疗慢性前列腺炎的作用机制有关。
Objective To investigate the therapeutic effect and mechanism of qianyu on chronic prostatitis Methods The pathological models of chronic bacterial prostatitis （CBP） and non-bacterial prostatitis were respectively established by injecting standard E. Coli and carrageenan into the rat＇s prostate. And the two models were respectively treated with qianyu treatment group and qiardietai control group to observe its effect. The immunity in the rat＇s prostate （SIgA and IL-8 ） was examined by IR and ELISA. Results As compared the treatment of qianyu on CBP model with the model control group, there were respective significant differences （P 〈 0.05 ） in the level of SIgA and IL-8 between the two groups. Conclusion Qianyu may markedly improve the local immunity in CBP model of rat＇s prostate. It has the effects of repairing prostatic tissue, and alleviating mesenchymal inflammatory reaction. The effect of qianyu to regulate the local immunity in the rat~ prostate may be its mechanism in the treatment of chronic prostatitis.
出处
《医药导报》
CAS
2006年第11期1144-1146,共3页
Herald of Medicine
