繁缕中的黄酮碳苷类化合物(英文)

C-glycosylflavones from Stellaria media

目的:研究繁缕中的黄酮类化合物。方法:95%的乙醇提取物的水混悬液依次用石油醚、乙酸乙酯和正丁醇萃取,各种柱层析进行分离纯化,UV,NMR等波谱数据进行结构鉴定。结果:从中分离得到14个黄酮碳苷类化合物,其结构鉴定为:芹菜素(apigenin)(1),芹菜素-6,8-二-C-β-D-吡喃葡萄糖苷(2),即新西兰牡荆苷-2[vicenin-Ⅱ(6,8-二-C-β-D-glucopyranosylapigenin)],芹菜素-6-C-β-D-葡萄糖-8-C-β-D-半乳糖苷(8-C-β-D-galactopyranosylisovitexin(6-C-β-D-glucopyra-nosyl-8-C-β-D-galactopyranosylapigenin)(3),芹菜素-6-C-β-D-半乳糖-8-C-β-D-葡萄糖苷(6-C-β-D-galactopyranosylvitexin6-C-β-D-galactopyranosyl-8-C-β-D-glucopyranosylapigenin)(4),芹菜素-6,8-二-C-α-L-阿拉伯糖苷(6,8-di-C-α-L-arabinopyranosylapi-genin)(5),芹菜素-6-C-β-D-葡萄糖-8-C-α-L-阿拉伯糖苷[schaftoside(6-C-β-D-glucopyranosyl-8-C-α-L-arabinosylapigenin)](6),芹菜素-6-C-α-L-阿拉伯糖-8-C-β-D-葡萄糖苷[isoschaftoside(6-C-α-L-arabinosyl-8-C-β-D-glucopyranosylapigenin)](7),芹菜素-6-C-β-D-半乳糖-8-C-α-L-阿拉伯糖苷(6-C-β-D-galactopyranosyl-8-C-α-L-arabinosylapigenin)(8),芹菜素-8-C-β-D-半乳糖(8-C-β-D-galactosylapigenin)(9),牡荆素[vitexin(8-C-β-D-glucopyranosylapigenin)](10),异牡荆素[isovitexin(6-C-β-D-glucopyra-nosylapigenin)](11),麦黄酮-6,8-二-C-β-D葡萄糖苷(tricetin6,8-di-C-β-D-glucopyranoside)(12),麦黄酮-6-C-α-L-阿拉伯糖-8-C-β-D-葡萄糖苷[tricetin6-C-α-L-arabinosyl-8-C-β-D-galactopyranoside](13),7-O-β-D-葡萄糖基-6-C-β-D-葡萄糖(6″-乙酰基)芹菜素[7-O-β-D-glucopyranosyl-6-C-β-D-6″-acetyl-glucopyranosylapigenin](14)。结论:9个化合物(3～8及12、13)为首次从该植物中分离得到,化合物14为新化合物。

AIM： To isolate the chemical constituents from the aerial parts of Stellaria media （L.） Cyr.. METHODS： The compounds were isolated through column chromatography and recrystallization. The structures were elucidated by means of physio-chemical data and spectroscopy. RESULT： Fourteen C-Glycosylflavones were isolated from this plant, and their structures were elucidated as apigenin （1） , vicenin （6,8-di- C-β- D-glucopyranosyl apigenin） （2）, 8- C- β- D-galactopyranosyl isovitexin（6- C-β- D-glucopyranosyl-8- C-β- D-galactopyranosyl apigenin） （3）, 6- C-β- D-galactopyranosyl vitexin （ 6- C-β- D-galactopyranosyl-8- C-β- D- glucopyranosyl apigenin） （4）, 6, 8- di- C-α- L- arabinopyranosyl apigenin （5）, schaftoside （ 6- C-β- D-glucopyranosyl-8- C-α- L- arabinosyl apigenin） （6）, isoschaftoside （ 6- C-α- L -arabinosyl-8- C-β- D- glucopyranosyl apigenin ） （ 7 ）, 6- C- β- D- galactopyranosyl- 8- C- α- L- arabinosyl apigenin （ 8 ）, 8- C- β- O - galactosyl apigenin （9）, vitexin （8-C-β-O-glucopyranosyl apigenin） （10）, isovitexin （6-C-α-O-glucopyranosyl apigenin） （11）, tricetin 6,8- di-C-β-D-glucopyranosyl （12） , tricetin 6-C-α-L-arabinosyl-8-C-β-D-glucopyranosyl （13） and 7-O-β-D-glucopyranosyl-6- C-β-D-6＂-acetyl-glucopyranosyl apigenin （14）. CONCLUSIONS：Compounds 3 - 8 and compounds 12 and 13 have been found in the plant for the first time, and compound 14 is a new C-glycosylflavone.