肠道线虫感染连续选择性化疗10年效果分析

Analysis on the effect of selective chemotherapy continually on intestinal nemathelminth infections in human in 10 years

目的分析试点村人群肠道线虫感染连续选择性化疗的效果，为防治提供依据。方法用改良Kato法和饱和盐水浮聚法对试点村人群进行肠道线虫感染普查，虫卵阳性者主要用阿苯达唑300mg和复方甲苯达唑375mg，1．5d疗法，连续选择性化疗10年。运用统计软件R2．2．1建立负二项模型拟合数据，统计分析疗效。结果试点人群肠道线虫总感染率从化疗前的89．73％降至化疗后的1．28％。钩虫感染率和感染度从58．79％和526．29降至1．08％和56．91，均呈“L”型下降趋势。感染率和感染度在第1～3次化疗后即出现低水平波动。蛔虫感染率和感染度从51．14％和25311．23均降至0。鞭虫感染率和感染度从64．17％和439．46降至0．20％和14．00。结论连续选择性化疔可使人群肠道线虫感染率和感染度迅速下降，并维持在较低水平。

Objective To analyze the effect of the selective chemotherapy on intestinal nemathelminth infection in hu man. Methods The methods of improved Kato＇s thick smear and saturated brine floatation were used to detect the in testinal nemathelminth eggs in feces in testing villages, the egg positive cases were treated with albendazole 300 mg and eo-mebendazole 375 mg in combination in 1, 5 days. The sample group of patients in testing village was consecutively given a selective chemotherapy for 10 years. The negative binomial distribution was used to analyze the data by the statistic software R 2.2.1. Results The intestinal nemathelminth infection rate decreased from 89.73% before the chemotherapy to 1.28%. The hookworm infection rate decreased from 58. 79% to 1. 08% and the mean eggs per gram （EPG） changed from 526.29 to 56.91. Both of them decreased as a ＂L＂ shape. The infection rate and the mean EPG fluctuated at low level after the first to third chemotherapy. The infection rate of Ascaris lumbricoides decreased from 51.14% to 1. 28% and the mean EPG changed from 25 311. 23 to 0. The infection rate of Trichuris trichiura decreased from 64.17% to 0.20% and the mean EPG changes from 439.46 to 14.00. Conclusion The selective chemotherapy can rapidly decrease the infection rate and the mean EPG of the intestinal nemathelminth and keep them at lower level.